Recombinant Mouse L-dopachrome tautomerase(Dct)

Code CSB-CF006562MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P29812
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Mus musculus (Mouse)
Source in vitro E.coli expression system
Gene Names Dct
Protein Names Recommended name: L-dopachrome tautomerase Short name= DCT Short name= DT EC= name(s): L-dopachrome Delta-isomerase SLATY locus protein Tyrosinase-related protein 2 Short name= TRP-2 Short name= TRP2
Expression Region 24-517
Tag Info 10xHis-SUMO-tag
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)
Involvement in disease The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane.
Subcellular Location Melanosome membrane, Single-pass type I membrane protein, Melanosome
Protein Families Tyrosinase family
Tissue Specificity Melanocytes and retinal pigmented epithelium.
Database Links

KEGG: mmu:13190

STRING: 10090.ENSMUSP00000022725

UniGene: Mm.19987

Pathway Melanogenesis

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