Recombinant Mouse Neuronal pentraxin-1 (Nptx1)

1. Neuronal pentraxin 1 accumulates on the postsynaptic terminal forming functional synapses. PMID: 29024665
2. work highlights a potential role for synaptic proteins, such as NP1 and glutamate receptors in lysosomal storage diseases. PMID: 28007910
3. Results demonstrate a novel mechanism of neuronal death and predict that inhibition of NP1 expression is a promising strategy to prevent hypoxic-ischemic injury in immature brain PMID: 25554688
4. results demonstrate that extracellular release of NP1 promote hypoxic-ischemic neuronal death possibly via surface clustering with GluR1 at synaptic sites and that NP1, not its family member NP2, is involved in the neuronal death mechanisms PMID: 25526743
5. Genetic deletion of NP1 prevents hypoxic-ischemic neuronal death by reducing synaptic clustering of GluR1. PMID: 23525449
6. These findings suggest that Narp in the mPFC mediates the extinction of morphine conditioned place preference. PMID: 23322555
7. our findings demonstrate a novel mechanism by which NP1 regulates mitochondria-driven hippocampal cell death PMID: 23069675
8. NP1 facilitates the accumulation of BCL2-associated X protein (BAX) in mitochondria and regulates mitochondrial dynamics during apoptosis in mouse cerebellar granule neurons in culture. PMID: 22279230
9. Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3alpha/beta dependent mechanism PMID: 21130869
10. data indicate that the loss of NP1/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections PMID: 20392962
11. The Id3 and NP1 genes become transcriptionally active after MyoD induction in undifferentiated myoblasts. This is a stable, heritable event that does not need continued MyoD activity & is not subject to negative regulation by activated H-Ras G12V. PMID: 12167713
12. Neuronal pentraxin 1 and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 and 2) PMID: 16763034
13. Neuronal activity regulated pentraxin has a selective role in processing sensory-specific information necessary for appropriate devaluation performance, but not in general motivational effects of reward-predictive cues on performance. PMID: 18057201
14. NP1 enhances synaptogenesis and glutamate signaling by clustering AMPA receptors. PMID: 18840757

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KEGG: mmu:18164

STRING: 10090.ENSMUSP00000026670

UniGene: Mm.5142