Recombinant Mouse Proto-oncogene vav (Vav1), partial

1. the depletion of the micro RNA processing enzyme dicer in Vav1-positive cells allows interfering with post-yolk sac microglia recruitment PMID: 29704636
2. this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1. PMID: 26990002
3. Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells. PMID: 29136506
4. Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 stability PMID: 27188442
5. Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation PMID: 27438086
6. provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively. PMID: 25455592
7. Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment. PMID: 25538043
8. The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface. PMID: 23391492
9. analyses revealed a SHP2- and Lyn-dependent pathway leading to phosphorylation of Vav1, Rac activation, and F-actin polymerization in SCF-treated BMMCs PMID: 24733849
10. Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 production. PMID: 24532586
11. Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. PMID: 23825946
12. Suggest that Vav1 act as critical molecular link coupling hyperlipidemia with proatherogenic monocyte/macrophage responses. PMID: 23825362
13. Loss of Vav1 activity does not favour development of colitis-associated colon cancer. PMID: 23435399
14. SAP couples SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation. PMID: 22683124
15. the GDP exchange factor activity is required for T cell mediated allograft rejection PMID: 22456277
16. The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization. PMID: 22474331
17. Dectin-1 activates the integrin Mac-1 in neutrophils via Vav1 and Vav3 signaling to promote Candida albicans clearance. PMID: 22177564
18. identified previously unknown components of the CD36 signaling pathway, demonstrating that Vav proteins regulate oxLDL uptake and foam cell formation via calcium- and dynamin 2-dependent processes PMID: 21865158
19. Data show that abnormal perivascular localization correlated with decreased retention of Vav1(-/-) HSPC in the bone marrow (44-60% reduction at 48 h posttransplant. PMID: 21606370
20. Cbl inactivation reverses the deficiency of T cell development in Vav1 knockout mice PMID: 21490975
21. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade PMID: 21206905
22. CD36 contributes to activation of Vav-1, -2, and -3 in aortae from hyperlipidemic mice PMID: 21209086
23. Either Vav1 or P-Rex1 alone can produce sufficient active Rac for G protein-coupled receptor (GPCR)-dependent cell responses but under normal circumstances both contribute, presumably to ensure robust cell responses of primary neutrophils. PMID: 21178006
24. Themis2 was inducibly tyrosine phosphorylated upon LPS challenge and interacted with Vav (P27870). PMID: 20644716
25. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
26. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
27. These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. PMID: 20011522
28. GEF activity of Vav1 was not required for TCR-induced calcium flux, activation of extracellular signal-regulated kinase and protein kinase D1, and cell polarization PMID: 20009105
29. Study reports the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1; the catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes. PMID: 20141838
30. propose here a model in which Vav functions primarily as a tyrosine phosphorylated linker-protein for TCR activation of T cells PMID: 19672294
31. Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway PMID: 11790798
32. Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain. PMID: 11885979
33. novel role for Vav1 in the regulation of TCR-induced integrin clustering and cell adhesion PMID: 11911819
34. Vav regulates phagocytosis through subsequent catalysis of GDP/GTP exchange on Rac PMID: 11950933
35. Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. PMID: 11956228
36. transduces T cell receptor signals to the activation of phospholipase C-gamma1 via pi 3-kinase dependent and indepent pathyways PMID: 11994416
37. A component of transcriptionally active complexes PMID: 11994417
38. Vav contains pleckstrin homology and cysteine-rich domains critical for signaling PMID: 12177050
39. Results indicate that several Vav domains (Dbl homology, pleckstrin homology, and zinc finger) are essential for all the biological activities tested, whereas others are required for discrete, cell type-specific biological effects. PMID: 12228230
40. Vav1 contributes to platelet aggregation by CRP and thrombin, but is not required for regulation of phospholipase C. PMID: 12411320
41. Vav1(-/-) animals were resistant to MOG(35-55)-EAE since the priming and in vivo expansion of MOG-specific T cells was inefficient despite fully functional antigen presentation. PMID: 12799016
42. Vav is regulated by Cbl in human and mouse cells PMID: 12881521
43. Vav1 synergizes with or amplifies pathways acting through Rho/Rac GTPases and is essential for fully intact coupling of N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced signaling to downstream neutrophil functions. PMID: 14530369
44. Vav1 plays a role in LPS-mediated macrophage activation and iNOS production, and vav1 functions in part via activation of NF-IL-6. PMID: 15138177
45. Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. PMID: 15249579
46. Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity. PMID: 15365099
47. results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
48. PI3K activation is Vav-independent in response to strong signals delivered by multivalent cross-linking PMID: 15494014
49. full Vav transforming activation is mediated by the activation of multiple small GTPases and their subsequent activation of signaling pathways that regulate changes in gene expression PMID: 15634759
50. Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling PMID: 15845902

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KEGG: mmu:22324

STRING: 10090.ENSMUSP00000005889

UniGene: Mm.248172