Recombinant Mouse TNF receptor-associated factor 2 (Traf2)

1. Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine remarkably attenuated gut injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2, which was phosphorylated by PKCzeta at Ser(55), but not at Ser(11), under intestinal I/R or H/R conditions PMID: 28726782
2. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways. PMID: 26887372
3. Traf2 mediates the pro-survival pathway in the heart by suppressing necroptotic signaling. PMID: 28572508
4. Targeting TRAF2 may be useful as a therapeutic approach for immunosuppression-free islet allograft survival that avoids the thromboembolic complications associated with the use of anti-CD40L antibodies. PMID: 28062921
5. Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2. Ubiquitinated Nur77 then interacts with p62/SQSTM1, leading to autophagy of dysfunctional mitochondria and alleviation of inflammation. PMID: 28388439
6. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling PMID: 28489822
7. this study shows that TRAF2 and TRAF5 work as important regulators of the IL-6R signaling needed for Th17 development PMID: 27076680
8. TRAF2 functions as a key activator of MST1 in oxidative stress-induced intracellular signaling processes. PMID: 26698664
9. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. PMID: 25565375
10. These studies demonstrate a critical role for TRAF2 in the maintenance of peripheral CD8(+) CD44(hi) CD122(+) T-cell and NKT-cell homeostasis by modulating sensitivity to T-cell intrinsic growth factors such as IL-15. PMID: 25931426
11. HGK/MAP4K4 deficiency has a role in inducing TRAF2 stabilization and Th17 differentiation leading to insulin resistance PMID: 25098764
12. identifying the CYLD-TRAF2-p38MAPK pathway as a novel important regulator of HSC function restricting HSC cycling and promoting dormancy. PMID: 25824820
13. Data indicate that caspase-8 activity is lost upon deletion of c-FLIPL, and p43FLIP rescues caspase-8 activity through Raf1, TRAF2, and RIPK1 association, augmenting ERK and NF-kappaB pathways PMID: 24275659
14. IpaH0722 dampens the acute inflammatory response by preferentially inhibiting the PKC-mediated activation of NF-kappaB by ubiquitinating TRAF2, a molecule downstream of PKC, and by promoting its proteasome-dependent degradation. PMID: 23754945
15. Expression of endogenous TRAF2 is negligible in Traf2DN-transgenic B cells compared with wild-type mice. PMID: 22711886
16. hepatic TRAF2 cell autonomously promotes hepatic gluconeogenesis by enhancing the hyperglycemic response to glucagon. PMID: 22315325
17. Sex differences affected the response of myocardial tissues in dealing with cardiac endoplasmic reticulum stress in part through the regulation of SERCA2, CHOP, Ire1alpha and TRAF2. PMID: 20850991
18. TRAF2 plays a crucial role in controlling homeostasis of the colon. PMID: 21393251
19. Data show that MCPIP1 negatively regulates c-Jun N-terminal kinase (JNK) and NF-kappaB activity by removing ubiquitin moieties from proteins, including TRAF2, TRAF3, and TRAF6. PMID: 21115689
20. Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth. PMID: 20530691
21. Hence, our data show that the direct interaction between TRAF2 and MLK3 is required for TNF-alpha-induced activation of MLK3 and its downstream target, JNK. PMID: 19918265
22. TRAF2 is required for the activation of CD120b-mediated IgM secretion by B cells. PMID: 11907088
23. Regulation of TRAF2 signaling by self-induced degradation PMID: 11909853
24. Dominant negative gene inhibited activation of NF-kappa B, which was also inhibited in embryonic fibroblasts derived from null mice and mediated JNK activation in response to endoplasmic reticulum stress PMID: 12021180
25. TNFR-associated factor-2 binding site is critical for synergistic effects of CD40 and BCR signals. PMID: 12133933
26. An essential role of TRAF2-linked receptors is shown in secondary CD4 and CD8 T cell responses that has important implications for transplantation. PMID: 12218092
27. CD40 transgenes lacking specific binding sites were used to define the role of TRAF proteins in Ig class switiching. Binding to TRAF2 and/or TRAF3 but not TRAF6 is essential for CD40 isotype switching and activation in B cells. PMID: 12354380
28. Regulation of the subcellular localization by TRAF1 reveals the mechanism of signaling. PMID: 12370254
29. investigation as a target of Siah2 for ubiquitylation and degradation in vitro PMID: 12411493
30. TRAF2 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
31. TRAF2 exerts its antiapoptotic effect by regulating the expression of Kruppel-like factor LKLF PMID: 12897154
32. TRAF2 has roles in CD40 signaling in B lymphocytes PMID: 12958312
33. TRAF2 is involved in CD40 signaling PMID: 12960157
34. TRAF2 appears to be a critical adapter molecule that is required for both OX40-enhanced early T cell proliferation and the eventual conversion of these cells into long-lived memory T cells. PMID: 14634111
35. RIP, TRAF2, and FADD are crucial in mediating ROS accumulation in TNF-induced necrotic cell death PMID: 14701813
36. role of RIP and TRAF2 and lipid rafts in the transduction of cell death signal initiated by H(2)O(2); activation of c-jnk1 is a critical event downstream of RIP and TRAF2 in mediating ROS-induced cell death PMID: 15199146
37. TRAF2 is a multifunctional regulator of NF-kappaB activation that mediates activation of the canonical pathway but acts as a negative regulator of the noncanonical pathway. PMID: 15539150
38. TRAF2DN/Bcl-2 double-transgenic mice developed small B cell lymphoma progressing to leukemia PMID: 15545599
39. role of TRAF2 in regulating endoplasmic reticulum stress responses and the role of NF-kappaB in protecting cells from ER stress-induced apoptosis PMID: 16299380
40. Poly(ADP-ribose)polymerase-1 signaling to mitochondria in necrotic cell death requires Traf2-mediated JNK1. PMID: 16446354
41. an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK PMID: 16446357
42. role for the TNFR1-TRAF2-RelA-dependent canonical pathway in the development of Peyer's patches through up-regulation of cxcl13 mRNA. PMID: 17277132
43. The active caspase-8c-FLIP complex forms in the absence of Fas (CD95/APO1) and associates with the NF-kappaB signaling molecules RIP1, TRAF2, and TRAF6, as well as upstream NF-kappaB regulators PKC theta, CARMA1, Bcl-10, and MALT1 PMID: 17462996
44. TRAF2 and TRAF3 were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in mature B cells. PMID: 18313334
45. OIP-1 decreased (3.5-fold) measles virus nucleocapsid protein induced TRAF2 expression during osteoclast differentiation PMID: 18348201
46. place TRAF2 directly in the signaling pathway transduced through the IFNAR1 subunit of the IFN receptor PMID: 18362156
47. Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells. PMID: 18606850
48. TRAF2 and TRAF3 play essential and nonredundant roles in the alternative NF-B pathway PMID: 18997792
49. the degradation of NIK occurs upon assembly of a regulatory complex through TRAF3 recruitment of NIK and TRAF2 recruitment of cIAP1 and cIAP2. PMID: 18997794
50. TRAF2 plays a critical role in TNF signaling by directing the IKK complex to the membrane, promoting TRAF2 K63-linked ubiquitination, and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase. PMID: 19150425

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KEGG: mmu:22030

STRING: 10090.ENSMUSP00000028311

UniGene: Mm.3399