Recombinant Mouse Transcription factor HES-1 (Hes1)

1. this paper shows that epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis PMID: 29297498
2. miR-374b regulates the proliferation and differentiation of neural stem cells through targeting Hes1. Overexpression of Hes1 reverses the effect of miR-374b overexpression on neural stem cells differentiation. PMID: 29902458
3. Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. PMID: 30090006
4. the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas . PMID: 30093553
5. These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E(-/-) mice, in which downregulation of hes1 and hes5 is involved. PMID: 29171783
6. Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina. PMID: 28675662
7. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development PMID: 28655839
8. Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells. PMID: 27405330
9. inhibition of PTEN by Notch1/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy PMID: 29496446
10. this paper shows the critical role of the Notch1-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation PMID: 28286920
11. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process PMID: 29070679
12. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch. PMID: 28974640
13. that HIF-1alpha but not HIF-2alpha is able to interact with either GA-binding protein alpha or GA-binding protein beta1 PMID: 28602625
14. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target. PMID: 28536281
15. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus. PMID: 27537524
16. Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults. PMID: 27639167
17. the RBPjkappa-dependent Notch targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy. PMID: 27160681
18. this study identifies Hes1 as a homeostatic suppressor of inflammatory responses that exerts its suppressive function by regulating transcription elongation PMID: 27322654
19. This study demonstrated that Hes1 and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development. PMID: 26348989
20. We found that miR-21 acts as a bidirectional switch in the formation of IPCs by regulating the expression of target and downstream genes (SOX6, RPBJ and HES1). PMID: 26655730
21. Insm1-dependent Hes1 repression is required for neuroendocrine development. PMID: 26453796
22. Findings suggest the strict spatio-temporal expression of Notch effector genes plays an important role during hippocampal neurogenesis and suggests that Notch1, Hes1 and Ngn2 were regulated by changing some specific CpG sites of their promoters PMID: 25701255
23. Hes1-mediated Notch activity determines the plasticity of adult pancreatic duct cells and that there may exist a dosage requirement of Sox9 for keeping the duct cell identity in the adult pancreas. PMID: 25687338
24. found that Hes1 was deubiquitinated and stabilized by Usp27x and its homologs ubiquitin-specific protease 22 (Usp22) and ubiquitin-specific protease 51 PMID: 25846153
25. Results suggest that Hes1 represents a negative regulator of adult neurogenesis post-traumatic brain injury (TBI) and that the precise space-time regulation of Hes1 expression in the dentate gyrus may promote the recovery of neural function following TBI PMID: 25084035
26. Notch signaling can directly downregulate MUC5AC promoter activity through Hes1-dependent mechanisms. PMID: 23860410
27. results indicate that HES1 acts as a master repressor, the silencing of which is required for proper glucocorticoid signaling. PMID: 24300895
28. Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis. PMID: 24486648
29. delivery of siRNA to Hes1 and Hes5 using a transfection reagent or siRNA to Hes1 encapsulated within nanoparticles increased hair cell numbers in non-toxin treated organotypic cultures of cochleae and maculae PMID: 23850665
30. Curcumin reduced arginase activity and up regulated TGF-beta1 and HES-1 transcripts in mice. PMID: 22982865
31. Hes1 and Hes5 regulate vascular remodeling and arterial fate specification of endothelial cells in the development of the brain; they are critical transducers of Notch signals in brain vascular development. PMID: 23871867
32. Our data indicate that the development of pharyngeal organs and survival of neural-crest-derived mesenchyme in pharyngeal arches are critically dependent on Hes1. PMID: 23686616
33. Hes-1 downregulation allows PDX-1 to act as a major determinant of cholangiocyte proliferation in response to cholestatic injury. PMID: 23207146
34. miR-1 promotes the differentiation of MSCs into cardiac lineage in part due to negative regulation of Hes-1 PMID: 23509692
35. Data indicate that Notch1 and Notch2 are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch-inducible genes, Hes1 and Hey2, was elevated in LRCs. PMID: 23199335
36. In the postnatal retina, NOTCH2, as well as the Notch downstream genes, HES1 and SOX9, were detected in VSX2/Cyclin D1/SOX2-expressing cells in the postnatal retina, and in the mature retina NOTCH2 was most abundant in Muller glia PMID: 23277114
37. Differential expression of Hes1 between hematopoietic stem cells and hematopoietic progenitor cells resulted in the distinct responses of these cells to the leukemic condition. PMID: 23255132
38. Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation PMID: 23325756
39. The results indicate that Jagged-1-Hes-1 signaling can suppress the skewing of CD4+ T cells toward Th17 cells via RORgammat, for which Hes-1 may be crucial. PMID: 23489689
40. Notch-Hes1 pathway regulates ovarian somatic cell development, which is necessary for oocyte survival and maturation. PMID: 23274689
41. Hes1 repressor is essential regulator of hematopoietic stem cell development downstream of Notch signaling. PMID: 23267012
42. Hes1 expression dynamics in developing brain is regulated by MicroRNA9. PMID: 23134481
43. MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop. PMID: 22840391
44. The results suggest that Hes1 plays a critical role in regulating the development of neural crest derivatives in the mouse cervical region. PMID: 22689348
45. These results point to HES1, via repression of PTEN, and c-Myc as critical mediators of Notch function at the beta-selection checkpoint. PMID: 22649105
46. the expression levels of Hes1 transcripts were also significantly decreased in denervated eyes. PMID: 22232434
47. in Apc mutation-induced intestinal tumors, inactivation of Hes1 was sufficient for reducing tumor cell proliferation and inducing differentiation of tumor cells; results indicate Hes genes cooperatively regulate intestinal development and homeostasis PMID: 22318232
48. seven conserved DNA sequence blocks, representing the hes1 promoter and six novel cis-regulatory modules PMID: 22167192
49. The co-repressor recruitment mediated through WRPW domain of Hes-1 has contributed to the repressive effect. PMID: 21744064
50. Hes1, Atoh1, and Gfi1b form a fate-determining Notch signaling driven ternary switch in the developing intestinal epithelium. PMID: 22185794

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KEGG: mmu:15205

STRING: 10090.ENSMUSP00000023171

UniGene: Mm.390859