Recombinant Rat G1/S-specific cyclin-D3(Ccnd3)

Code CSB-YP004814RA
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Source Yeast
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Code CSB-EP004814RA
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Source E.coli
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Code CSB-EP004814RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004814RA
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Source Baculovirus
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Code CSB-MP004814RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ccnd3
Uniprot No. P48961
Alternative Names Ccnd3G1/S-specific cyclin-D3
Species Rattus norvegicus (Rat)
Expression Region 1-293
Target Protein Sequence MELLCCEGTR LAPRAGPDPR LLGDQRVLQS LLRLEERYVP RGSYFQCVQK EIKPHMRKML AYWMLEVCEE QRCEEDVFPL AMNYLDRYLS CVPTRKAQLQ LLGTVCLLLA SKLRETTPLT IEKLCIYTDQ AMAPWQLREW EVLVLGKLKW DLAAVIAHDF LALILHRLSL PSDRQALVKK HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVLGLGACSM SADELTELLA GITGTEVDCL RACQEQQIEA ALRESLREAA QTAPSPVPKA PGGSSSQGPS QTSTPTDVTA IHL
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Gene References into Functions
  1. Dexamethasone induced placental and embryonal abnormalities which could be associated with reduced expressions of PCNA and cyclin D3, increased expressions of p27 and p57 and increased rate of apoptosis in IUGR placentas PMID: 25596037
  2. role of cyclin D3/CDK11(p58) complex in repressing the Schwann cells proliferation and inducing its apoptosis PMID: 20066559
  3. cyclin D3 expression is regulated through different pathways and plays a distinct role in the liver PMID: 12085346
  4. Cyclin D3 is rate limiting for G1 progression in thyroid follicular cells and that its constitutive upregulation by chronic stimulation of the TSH/cAMP pathway plays a role in human and experimental hyperproliferative diseases of the thyroid gland. PMID: 14576819
  5. liver development is associated with a switch from cyclin D2/D3-containing complexes to cyclin D1:cyclin-dependent kinase 4 complexes PMID: 15809057
  6. Cyclins D1 and D3 act as sensors of the inhibition of gap junctional communication in astrocytes. PMID: 16412096
  7. These data suggested that both CDK11 and cyclin D3 may play important roles in spinal cord pathophysiology. PMID: 18008145
  8. cyclin D3 is a central coordinator that controls the organization of a complex set of proteins that regulate autophagy, formation of the monocyte-adhesive hyaluronan matrix, and C/EBPalpha-mediated lipogenesis PMID: 19276076
  9. Cyclin D3 is a central coordinator that controls the organization of a complex set of proteins that regulate autophagy and subsequent formation of the monocyte-adhesive hyaluronan matrix. PMID: 19550149
  10. PGE(2) induces mesangial cell hypertrophy and cell cycle arrest via its EP1 receptor. PMID: 19672123

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Subcellular Location Nucleus, Cytoplasm, Membrane
Protein Families Cyclin family, Cyclin D subfamily
Database Links

KEGG: rno:25193

STRING: 10116.ENSRNOP00000064704

UniGene: Rn.3483

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