Recombinant Rat Inositol 1,4,5-trisphosphate receptor type 1 (Itpr1), partial

1. IP3RI protein expression is increased in the kidney of hepatorenal syndrome rats, and may be regulated at the transcriptional level. PMID: 30090007
2. These findings highlight previously unidentified functions for IP3R isoforms in the heart with specific implications for hypertrophic signaling in animal models and in human disease. PMID: 28923351
3. Data suggest that proteolytic processing of Itpr1 may represent a novel form of modulation of Itpr1 channel function and increases the repertoire of Ca2+ and PKA (protein kinase A) signaling achievable through inositol 1,4,5-trisphosphate/Itpr1 signal transduction. PMID: 28526746
4. Our findings indicate that sustained SOCC activity, together with that of the sarco-endoplasmic reticulum Ca(2+)-ATPase, contribute to the maintenance of astrocytic Ca(2+) store levels, ultimately enabling astrocytic Ca(2+) signaling. PMID: 28336440
5. InsP3 R-I-dependent Ca(2+) signalling is an early triggering pathway required for liver regeneration. PMID: 24814243
6. These results demonstrated, for the first time, that IP3R physically interacts with Cx43 and participates in the regulation of Cx43 phosphorylation on S279/282, thereby affecting GJ intercellular communication in ventricular myocytes PMID: 25262337
7. Overexpression of the Cys-->Ala mutated rat IP3R1 in Jurkat T cells reduced Ca2+ flux in response to T-cell receptor stimulation with anti-CD3, but did not alter thapsigargin-induced Ca2+ flux. PMID: 25368151
8. a pleiotropic enzyme transglutaminase type 2 targets the allosteric coupling domain of IP3R type 1 (IP3R1) and negatively regulates IP3R1-mediated calcium signaling and autophagy by locking the subunit configurations. PMID: 25201980
9. IP3R up-regulation in VSM is associated with enhancement and sensitization of IP3-dependent Ca(2+) release, resulting in increased VSM contraction in response to agonist stimulation. PMID: 24097979
10. The study demonstrates low-affinity interactions between the N-terminal domains of an intracellular Ca(2+) channel, the type 1 inositol 1,4,5-trisphosphate receptor. PMID: 23555994
11. CaBP1 binds via its C lobe to the cytosolic N-terminal region (NT; residues 1-604) of InsP3R1. PMID: 23650371
12. novel insights regarding the regulation of IP3R1 during proteolysis and provide direct evidence that polypeptide continuity is not required for IP3R activation and Ca(2+) release. PMID: 23479737
13. Inositol 1,4,5-trisphosphate and IP3 receptors act as inhibitors of autophagic processes in cardiomyocytes. PMID: 23137780
14. An endogenous binding motif, 1-8-14, mediates conformational changes that are essential to IP3R activation. PMID: 23009366
15. Data suggest that interfering physical and functional coupling between type 1 inositol 1,4,5-trisphosphate receptors (IP3R1) and transient receptor potential 3 channels (TRPC3) may be a therapeutic strategy to induce vasodilation in hypertension. PMID: 23045459
16. This study demonstrated that InsP(3)R1 proteolysis disrupts neuronal Ca(2+) homeostasis, and potentially acts as a feed-forward pathway to initiate or execute neuronal death. PMID: 22762283
17. IP3R1 localization via protein 4.1N is necessary for divalent calcium ion wave (Ca2+) formation, which in turn mediates neurite formation. PMID: 21389686
18. Our clone had 99% similarity with the rat brain IP(3)R1 sequence; the exceptions were 39 amino acid deletions at the position of 1693-1731, and the deletion of phenylalanine at position 1372 that lay in the regulatory region. PMID: 22207335
19. comparison of key domains in InsP3 and ryanodine receptors PMID: 22286060
20. calpain cleaves InsP(3)R1 in a clinically relevant injury model, suggesting that Ca(2+) leak through the proteolyzed channel may act as a feed-forward mechanism to enhance cell death. PMID: 21859719
21. high variance in the cytoplasmic region of IP3R1n shown by cryo-electron microscopy could be attributed to genuine structural flexibility PMID: 21827954
22. in arterial smooth muscle cells, cav-1 co-localizes SR IP(3)R1 and plasma membrane TRPC3 channels in close spatial proximity thereby enabling IP(3)-induced physical coupling of these proteins, leading to I(Cat) generation and vasoconstriction PMID: 21098487
23. all IP(3)R types are subject to ubiquitination at approximately the same locations and that, independent of cell type, IP(3)Rs are modified by monoubiquitin and Lys-48- and Lys-63-linked ubiquitin chains, although in differing proportions PMID: 21071436
24. IP(3)R1 activation elevates BK(Ca) channel apparent Ca(2+) sensitivity through local molecular coupling in arterial smooth muscle cells. PMID: 20713546
25. IP(3) stimulates direct coupling between IP(3)R1 and membrane-resident TRPC3 channels in arterial myocytes, leading to cation activation and vasoconstriction. PMID: 20378853
26. Increased InsP(3)R expression may be a general phenomenon that underlies Ca(2+) changes during hypertrophy. PMID: 19934645
27. Data conclude that for IP3R approx. 30 residues after TMD1 must be translated to allow a signal sequence within TMD1 to be extruded from the ribosome and mediate co-translational targeting to the ER. PMID: 19845505
28. results indicate the InsP3R channel does not significantly differ functionally in terms of Ca2+ release rates between isoforms PMID: 11587548
29. Results show that the interaction of calmodulin with the high-affinity Ca(2+)-CaM-binding site of inositol triphosphate receptor 1 does not play a direct role in biphasic modulation of the receptor by cytosolic Ca(2+) or in receptor inhibition by CaM. PMID: 11972451
30. Regulation of Ca(2+) signaling in rat bile duct epithelia PMID: 12143036
31. IP3R1 signaling is regulated by PKA, PP1 and PP2A in rat brain PMID: 12167631
32. immobilization stress elevates mRNA of type 1 and 2 IP(3) receptors, mainly through the glucocorticoid responsive element PMID: 12435588
33. Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue PMID: 12623131
34. Repeated immobilization stress reduces the gene expression and protein levels in stellate ganglia PMID: 12820984
35. InsP3-mediated Ca(2+) signaling in bile duct epithelia appears to be important for normal bile secretion in the liver, and loss of InsP3Rs may be a final common pathway for cholestasis. PMID: 14517800
36. InsP(3)R1-PKA association is mediated by AKAP9; InsP(3)R1-AKAP9 binding promotes association of neuronal InsP(3)R1 with the NR1 NMDA receptor; and neuronal InsP(3)R1 associate with PP1 directly via carboxy-terminus and indirectly via AKAP9 PMID: 14982933
37. 4.1N serves as a linker protein between IP3R1 and actin filaments PMID: 15364918
38. Subject to alternative RNA splicing, with 7 sites of transcript variation, 6 within the open reading frame. PMID: 15739177
39. The nuclear membrane of Purkinje neurones also contained multiple InsP(3)- activated ion channels localized exclusively in the inner nuclear membrane with their receptor loci facing the nucleoplasm PMID: 15774532
40. These results show that gene expression of both type 1 and 2 IP(3) receptors is regulated by retinoic acid, although the effect of retinoic acid on mRNA levels of the type 1 IP(3) receptors is dependent on brain area. PMID: 15843050
41. Our study illustrates how the junctional membrane IP(3)R complex connects different signaling pathways to define the fidelity and specificity of Ca(2+) signaling. PMID: 15911880
42. Thus, cold exposure affects the response of the gene expression of the type 1 IP3 receptor to immobilization stress. PMID: 16118475
43. IP3R isoforms may display a range of divalent calcium ion sensitivities that are determined by multiple sites within the protein and markedly influenced by the affiinity of the receptor for PMID: 16198415
44. Type 1IP3 receptors predominate in intrinsic neuronal ganglia of cardiac atria. PMID: 16223514
45. These data point to the adrenergic modulation of the type 1 IP3 receptors in the rat hearts. PMID: 16377004
46. Results show that addition of neuronal calcium sensor-1 (NCS-1) to purified inositol 1,4,5-trisphosphate receptor type 1 (InsP3R1) increased the channel activity in both a calcium-dependent and -independent manner. PMID: 16691292
47. CIB1 is a ubiquitously expressed activating and inhibiting protein ligand of the InsP(3)R PMID: 16723353
48. it is concluded that most IP3R are expressed in intracellular stores but a tiny fraction is reliably directed to the plasma membrane, where they contribute substantially to the Ca2+ entry evoked by the B-cell receptor PMID: 16840702
49. Loss decreased the sensitivity of hepatocytes to vasopressin but had little effect on the initiation or spread of Ca(2+) waves across hepatocytes. PMID: 17284437
50. IP3R1 is clustered at the node of Ranvier, in a distribution that is similar to the Nav1.6 sodium channels in the sciatic nerve. PMID: 17496801

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KEGG: rno:25262

STRING: 10116.ENSRNOP00000063885

UniGene: Rn.2135