Recombinant Rat NF-kappa-B inhibitor alpha (Nfkbia)

1. Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IkappaBalpha/NFkappaB and Enhancing Nrf2/HO-1. PMID: 29147465
2. Data suggest that expression and phosphorylation of Nfkbia in adipose tissue can be altered by dietary factors; here, obese rats treated with anti-obesity dietary supplement taurine exhibit increased expression of Nfkbia and decreased ratio of phosphorylated/non-phosphorylated Nfkbia intra-abdominal adipose tissue (and decreased adiposity). PMID: 26621632
3. These results indicated that miR-199b attenuated acute spinal cord injury at least partly through IKKbeta-NF-kappaB signaling pathway and affecting the function of microglia. PMID: 27693495
4. enhanced miR-381a-3p expression contributed to the injury of osteoarthritis mainly by inhibiting the expression of IkappaBalpha. PMID: 27312547
5. Thus, the inhibition of the IKK complex might be an effective strategy for the prevention of multiple organ failure associated with hemorrhagic shock PMID: 26101953
6. TFPI inhibited MCP-3 expression induced by TNF-alpha; this effect may be propagated through the NF-kappaB/IkappaB-alpha pathway. PMID: 23374966
7. NF-kappaB signaling through IkappaBalpha degradation results in manganese superoxide dismutase (MnSOD) upregulation and preserved cell growth, whereas NF-kappaB signaling through IkappaBbeta degradation mediates apoptosis and P-selectin expression. PMID: 23418625
8. Data from an obesity model suggest that as duration of plasma free fatty acid elevation increases, the IKKB pathway in liver becomes inactivated leading to insulin resistance; levels of phospho-IkBa and IkBa in liver were monitored in this study. PMID: 23328071
9. a role for IKKalpha in accelerating the differentiation of human NPCs and identify IKKalpha as a potential regulator of MeCP2 function and BDNF expression PMID: 22848609
10. These results suggest the existence of a reservoir of monoubiquitylated IkappaBalpha resistant to TNFalpha-induced proteolysis. PMID: 22022389
11. Redox regulation of IkappaB-alpha nuclear transport and activation in rat PMID: 12200125
12. basal IkappaBalpha expression (and as a consequence NF-kappaB activity) is under the control of the various components of the CBF1/Notch signal transduction pathway PMID: 12700242
13. IKBA is degraded by HSP27 through the 26s proteasome PMID: 12897149
14. IKBA has a role in tumor necrosis factor-stimulated insulin resistance in skeletal muscle PMID: 14764603
15. anti-inflammatory effects of SP-A on LPS-challenged alveolar macrophages are associated with a SP-A-mediated direct modulation of the IkappaB-alpha turnover PMID: 15308505
16. diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type-dependent manner PMID: 16081881
17. the mechanism preventing septic activation of NF-kappaB is that oversynthesized HSP72 forms a complex with NF-kappaB/I-kappaB, thus inhibiting nuclear translocation of NF-kappaB PMID: 16135962
18. Results describe the coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. PMID: 16875840
19. IkappaBalpha degradation is required for the unloading-induced decrease in fiber size, the increase in protein ubiquitination, activation of NF-kappaB signaling, and the expression of specific atrophy genes PMID: 16928772
20. data suggest a new mechanism by which calpain 3 activation is able to regulate the IkappaBalpha/NF-kappaB pathway and thus neurodegenerative processes PMID: 16938483
21. indicate that anti-inflammatory macrophage activation via IkappaB-alpha by Surfactant protein A critically depends on protein kinase C zeta activity PMID: 17878344
22. alteration of NF-kappaB and I-kappa B might play an important role in aberrant proliferation within the intima and vascular remodeling following vascular injury PMID: 18278452

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KEGG: rno:25493

STRING: 10116.ENSRNOP00000009894

UniGene: Rn.12550