Recombinant Rat Rho-associated protein kinase 2 (Rock2), partial

1. The findings suggest that miRNA-139-5p is capable of significantly influencing the phenotypic tonicity of the internal anal sphincter smooth muscle via ROCK2. PMID: 28469189
2. acute hypobaric hypoxia augments ROCK2 protein level and activity PMID: 28657365
3. We conclude that normal pregnancy suppresses ROCKs, which contributes to the low contractility during pregnancy; the RhoA/ROCK signalling pathway might be a potential target for the development of new tocolytic agents. PMID: 28820400
4. High ROCK-II expression is associated with Diabetes-Induced Vascular Dysfunction. PMID: 23826343
5. Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2. PMID: 27288754
6. Rho-Kinase inhibitor fasudil inhibited high glucose-induced apoptosis in rat H9c2 cells through activating autophagy. PMID: 27333569
7. Increased contraction in the gastric smooth muscle of male rats is attributable to greater RhoA/ROCK activation independent of differences in the expression of ROCK isoforms or total RhoA. PMID: 26391686
8. ROCK2 regulates contractile force and Rac1 activity at the leading edge of migratory cells and the spine head of neurons. PMID: 26169356
9. Results demonstrate a clear role for ROCK in the development of LV dysfunction and impaired actin-myosin cross-bridge dynamics in early diabetic cardiomyopathy. PMID: 26194354
10. Tetramethylpyrazine protects against acute lung injury by affecting rhoA/ROCK2 signaling. PMID: 26191148
11. Rho kinase expression in the femoral artery during hindlimb unweighting and Rho kinase role in vasoconstriction in femoral arteries PMID: 25761652
12. ROCK-2 inhibition restores ET-1-mediated NO production after the LPS pretreatment, in part, through an increase in actin depolymerization PMID: 25243430
13. these results described a novel mechanism in atherosclerosis through PDGF-BB signaling in VSMC, in which MMP-2 expression is induced via extracellular signal-regulated kinases and p38 mitogen-activated protein kinase phosphorylation, as well as ROCK. PMID: 24792035
14. The gene therapy with lentiviral vector-based siRNA-targeting ROCK2 mRNA can significantly improve erectile function mainly by directly inhibiting ROCK2 pathway in the SHR PMID: 25260465
15. Over-activation of ROCK2 contributes to diabetic cardiomyopathy by multiple mechanisms, including direct phosphorylation and activation of protein kinase C beta II and interference with the PDK-1-mediated phosphorylation and activation of AKT. PMID: 24466133
16. Characterize ROCK2 as a specific therapeutic target in neurodegenerative diseases and demonstrate new downstream effects of ROCK2 including axonal degeneration, apoptosis and autophagy. PMID: 24832597
17. Suggest pantoprazole may impair gastric and lower sphincter muscle, exacerbating esophageal reflux via ROCK2 inhibtion. PMID: 24699328
18. Downregulation of the expression of active-RhoA, ROCK1 and ROCK2 by Y-39983 promotes axonal regeneration. PMID: 23258382
19. RhoA translocation but not ROCK-2 expression markedly increased by hyperosmolar glucose solution; the results may indicate that hyperosmolarity could induce vasoconstriction through Rho/Rho-kinase signalling PMID: 22136148
20. Kamolonol suppresses angiotensin II-induced stress fiber formation and cellular hypertrophy through inhibition of Rho-associated kinase 2 activity PMID: 23891689
21. ROCK2 is upregulated in vascular smooth muscle of diabetic aorta. PMID: 23530857
22. These results demonstrated that ROCK1 and ROCK2 could promote VSMC proliferation through ERK nuclear translocation, regulating the expression of PCNA and cyclin D1 protein. PMID: 23402758
23. Estrogens could up-regulate ROCK-2 in the rat coronary vascular endothelium through GPER1 and EGFR transactivation. PMID: 23641788
24. Spironolactone lowers portal hypertension by improvement of liver fibrosis and inhibition of intrahepatic vasoconstriction via down-regulating ROCK-2 activity and activating NO/PKG pathway PMID: 22479572
25. The rhoA/rhoA-associated kinase pathway is a key regulator of uterine activation during labor and may be a useful target for the prevention of spontaneous preterm birth. PMID: 22727353
26. Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury. PMID: 22031832
27. aldosterone induces contraction of activated hepatic stellate cells through the activation of the RhoA/ROCK-2 signaling pathway PMID: 21545816
28. results provide evidence that depolymerization of the cortical actin cytoskeleton via inhibition of RhoA or its effector ROCKII favors the recruitment of V-ATPase from the cytosolic compartment into the apical membrane in epididymal clear cells PMID: 21411727
29. ROCK-II may be dominant in enhancing survival of pulmonary arterial smooth muscle after rescue treatment with a Rho-kinase inhibitor in rats with chronic pulmonary hypertension. PMID: 20889845
30. Treatment of urethral smooth muscle cells with estrogen, raloxifene or levormeloxifene resulted in decreased expression of Rock-II in a dosage-dependent manner. PMID: 20970835
31. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate PMID: 11867620
32. Interferes with constriction induced by distinct signaling pathways in renal vessels without affecting F-actin structure. PMID: 12506136
33. Angiotensin II, KCl, and myogenic constriction of afferent arterioles require calcium entry through voltage-dependent calcium channels. Interaction between Rho/Rho-kinase and calcium entry may determine afferent arteriolar tone induced by these stimuli. PMID: 12902637
34. Chronic hypoxia mediates a shift in NO signaling to promote pulmonary vascular smooth muscle calcium desensitization through inhibition of RhoA/ROK. PMID: 15310556
35. An enhanced role for the ROK pathway in alpha1-adrenergic vasoconstriction in metabolic syndrome is reported. PMID: 16141308
36. Increased RhoA/Rho-kinase signaling is a major factor in the pathogenesis of age-associated erectile dysfunction and the mechanism involves increased penile smooth muscle contractility through inhibition of myosin light chain phosphatase. PMID: 16396994
37. Two rho kinases contribute to fibronectin matrix assembly in a different manner and cortical myosin II-driven contractility, but not stress fibers, may be critical in this activity. PMID: 17065553
38. ROCK activation occurs specifically during early myocardial reperfusion and contributes to irreversible myocardial damage. PMID: 17220176
39. RhoA/ROCK play a critical role in maintenance of spontaneous tone in the internal anal sphincter smooth muscle via inhibition of myosin light chain phosphatase. PMID: 17379756
40. both PKC and Rho/Rho-kinase mediate the heightened pulmonary vascular response to ET-1 in hypertensive pulmonary arterial smooth muscle PMID: 17468135
41. Thus ET-1-mediated signaling in aorta and sMA is altered by IH-C but is dependent on different second messenger systems in small vs. large arteries. PMID: 17720771
42. Rho-kinase activation with resultant eNOS down-regulation is substantially involved in the pathogenesis of portal hypertension in secondary biliary cirrhosis. PMID: 18167063
43. chronic hypoxia augments Ca(2+) sensitization through ROS-dependent activation of RhoA/ROK signaling in pulmonary vascular smooth muscle PMID: 18621909
44. lipid membrane binding properties of the PH-C1 tandem of rho kinases PMID: 18640982
45. ROCK1 and ROCK2 regulated myosin light chain phosphatase. ROCK isoforms had distinct and opposing effects on vascular smooth muscle cell (VSMC) morphology and ROCK2, but not ROCK1, had a predominant role in VSMC contractility. PMID: 19131646
46. ROCKII is regulated by localization to specific membrane compartments and its novel binding partner, Dynamin1. PMID: 19222995
47. Data indicate that RhoA/Rok is involved in substratum-mediated regulation of insulin signaling in MECs, and under the conditions where proper adhesion to BM is missing, insulin-mediated cellular differentiation and survival would be defective. PMID: 19391109
48. 15-hydroxyeicosatetraenoic acid protects pulmonary artery smooth muscle cells from apoptosis, contributing to pulmonary vascular medial thickening, and the effect is, at least in part, mediated via the ROCK pathway. PMID: 19746421

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KEGG: rno:25537

STRING: 10116.ENSRNOP00000006403

UniGene: Rn.88642