Code | CSB-RA257443A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The AGTR1 recombinant monoclonal antibody is created using recombinant DNA technology and is ideal for detecting human AGTR1 protein in ELISA and WB applications. First, the cDNA of the AGTR1 antibody-producing hybridomas is sequenced to synthesize the gene encoding the AGTR1 monoclonal antibody. The hybridomas are created by fusing B cells isolated from an animal that was immunized with a synthesized peptide derived from human AGTR1, with myeloma cells. The synthesized gene is then cloned into a vector. The recombinant vector is transfected into cells for cultivation. The resulting AGTR1 recombinant monoclonal antibody is purified using affinity chromatography from the cell culture supernatant.
The AGTR1 protein is a G protein-coupled receptor that is primarily expressed in vascular smooth muscle cells and the adrenal gland. It plays a key role in the regulation of the renin-angiotensin-aldosterone system (RAAS), which controls blood pressure and fluid balance in the body. Additionally, AGTR1 has been implicated in the pathogenesis of cardiovascular diseases such as hypertension, atherosclerosis, and heart failure, and is a target for pharmacological interventions.
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