Code | CSB-RA614990A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The recombinant CA9 antibody is a monoclonal antibody made in vitro using the CA9 antibody genes that are typically expressed from a plasmid in a stable mammalian cell line. The genes coding for the CA9 antibody will ultimately assemble into a fully functional antibody after translation. The synthesized antibody is the recombinant antibody against CA9. It underwent purification using affinity-chromatography. This recombinant CA9 antibody is suitable for use in the ELISA, IHC to detect the CA9 protein from Human.
CA9 is a hypoxia-induced isoenzyme that catalyzes the reversible metabolism of carbon to carbonic acid thus regulating intracellular pH homeostasis. CA9 possesses pleiotropic functions. As a survival factor, CD9 protects tumor cells from hypoxia and acidosis. It also serves as a pro-migratory factor encouraging cell movement and invasion, as a signaling protein converting intracellular signals to extracellular effects on adhesion, proteolysis, and other activities. Under hypoxic conditions, CA9 expression is dramatically upregulated in tumor cells, which aids in maintaining a normal intracellular pH while facilitating an acidic extracellular pH that promotes cancer progression. CA9 expression has been linked to poor clinical outcomes in malignancies of the head and neck, cervix, kidney, and lung.
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