Code | CSB-RA927191A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The DPP4 recombinant monoclonal antibody is generated through recombinant DNA technology and can be utilized for detecting human DPP4 protein in ELISA and IHC applications. To produce this antibody, the cDNA of the DPP4 antibody-producing hybridomas is sequenced and the gene that codes for the DPP4 monoclonal antibody is synthesized. Myeloma cells and B cells obtained from an animal that was immunized with a synthesized peptide derived from human DPP4 are fused to generate hybridomas. The synthesized gene is then cloned into a vector, which is transfected into cells for cultivation. Finally, the DPP4 recombinant monoclonal antibody is obtained from the cell culture supernatant through affinity chromatography purification.
The DPP4 protein, also known as CD26, is a serine exopeptidase that cleaves dipeptides from the N-terminus of proteins and peptides. In particular, DPP4 has been implicated in the regulation of glucose metabolism through its cleavage of incretin hormones such as GLP-1 and GIP, which stimulate insulin secretion from pancreatic beta cells. DPP4 has also been implicated in the regulation of immune function, including T-cell activation, migration, and proliferation.
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