DPP4

What is DPP4?

Dipeptidyl Peptidase 4 (DPP4), also called CD26 or adenosine deaminase complexing protein 2, is a protein in humans that is encoded by the DPP4 gene. The DPP4 was originally identified in 1996 through a multitude of chemistry studies by Hopsu-Havu VK and Glenner GG. It is a serine membrane-anchored exopeptidase belong to dipeptidyl peptidase subfamily 9b, with a wide distribution in several tissues, such as the lung, kidney, liver, gut, and immune cells. And it also exists as a soluble form circulates in the bloodstream and the body fluids.

What is the feature of the DPP4 structure?

The primary structure of DPP4 is composed of a short N-terminal cytoplasmic tail, a transmembrane domain, and an extracellular portion consisting of a flexible stalk, glycosylation‐rich region, cysteine‐rich region, and a C-terminal catalytic domain. There are two domains in the crystal/quaternary structure of DPP4, including an eight‐bladed propeller (blades II–V for the glycosylation‐rich region and blades VI-VIII for the cysteine‐rich region) and an α/β‐hydrolase domain.

What is the function of DPP4?

Sebastiano Bruno Solerte et al. showed that DPP4 distribution in the human respiratory tract may facilitate the viral entry into the airway tract itself and could contribute to the progression of cytokine storm and immunopathology in leading to lethal COVID-19 pneumonia.

Since DPP4 cleaves a broad range of substrates such as growth factors, chemokines, neuropeptides, and vasoactive peptides, it is involved in various physiological processes, including immune regulation, signal transduction, and apoptosis. The interactions between DPP4 and ADA, CD45, caveolin-1, CARMA-1, and M6P/IGFII-R, mediate the activation, signaling, and differentiation of T cells. Inhibition of the DPP4 enzyme by DPP4 inhibitors (DPP4is) such as sitagliptin, alogliptin, vildagliptin prolongs and enhances the activity of incretins, important players in insulin secretion and blood glucose control regulation. Therefore, DPP4 inhibitors are widely used for the therapies for hyperglycemia in type II diabetes.

Additionally, DPP4 is complicated in tumor biology and acts as a potential biomarker for multiple cancers, but it varies among different cancers. For example, the upregulation of DPP4 expression is found in numerous aggressive T-cell malignancies, lung adenocarcinoma, thyroid carcinoma, and prostate cancer. None the less, DPP4 is downregulated in endometrial adenocarcinoma.

Hot products of DPP4:

Recombinant Human Dipeptidyl peptidase 4 (DPP4) (in vitro E.coli expression system) (CSB-CF007139HU)

DPP4 Antibody (ELISA, WB, IHC, IF) (CSB-PA06229A0Rb)

DPP4 Antibody (ELISA,WB,IHC) (CSB-PA007139GA01HU)

DPP4 Antibodies

DPP4 Antibodies for Homo sapiens (Human)

DPP4 Antibodies for Rattus norvegicus (Rat)

DPP4 Proteins

DPP4 Proteins for Rattus norvegicus (Rat)

DPP4 Proteins for Mus musculus (Mouse)

DPP4 Proteins for Trichophyton equinum (Horse ringworm fungus)

DPP4 Proteins for Trichophyton tonsurans (Scalp ringworm fungus)

DPP4 Proteins for Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)

DPP4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

DPP4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)

DPP4 Proteins for Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)

DPP4 Proteins for Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)

DPP4 Proteins for Trichophyton verrucosum (strain HKI 0517)

DPP4 Proteins for Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)

DPP4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

DPP4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

DPP4 Proteins for Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)

DPP4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

DPP4 Proteins for Felis catus (Cat) (Felis silvestris catus)

DPP4 Proteins for Bos taurus (Bovine)

DPP4 Proteins for Sus scrofa (Pig)

DPP4 Proteins for Homo sapiens (Human)

DPP4 ELISA Kit

DPP4 ELISA Kit for Bos taurus (Bovine)

DPP4 ELISA Kit for Homo sapiens (Human)

DPP4 ELISA Kit for Mus musculus (Mouse)

DPP4 ELISA Kit for Sus scrofa (Pig)

DPP4 ELISA Kit for Rattus norvegicus (Rat)

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