LY6G6D Recombinant Monoclonal Antibody

LY6G6D belongs to the lymphocyte antigen 6 superfamily, a group of GPI-anchored cell surface proteins that play important roles in immune cell development and function. Also known as MEGT1 (megakaryocyte-enhanced gene transcript 1 protein), LY6G6D has garnered attention in immunology research for its involvement in immune cell signaling and its potential as a marker in various disease contexts.

This recombinant monoclonal antibody (clone 9H7) offers the consistency and reliability that demanding research protocols require. Because it is produced from a defined sequence rather than traditional hybridoma methods, you can expect uniform performance across different lots, eliminating the variability that can compromise longitudinal studies or multi-site collaborations. The mouse IgG1 isotype and affinity-chromatography purification ensure high purity, confirmed at greater than 95% by SEC-HPLC analysis.

Functional validation demonstrates robust binding activity across multiple species, providing genuine cross-species reactivity for translational research workflows. ELISA testing shows strong binding to human, mouse, rat, and cynomolgus macaque LY6G6D proteins, with EC50 values in the low nanogram per milliliter range across all species tested. Flow cytometry validation further confirms specificity, with clear discrimination between untransfected control cells and LY6G6D-transfected stable cell lines in both HEK-293T and CT26 backgrounds. For flow cytometry applications, dilutions of 1:50 to 1:200 provide optimal results.

Whether you are investigating immune cell populations, exploring LY6G6D as a potential biomarker, or conducting comparative studies across preclinical models, this antibody delivers the specificity and cross-species utility needed to advance your immunology research.