Code | CSB-RA963043A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
PLAU, also called Urokinase-type plasminogen activator (uPA), binds to uPAR inducing migration, adhesion, and proliferation through multiple interactions with G protein-coupled receptor FPRL1, integrins, or the epidermal growth factor (EGF) receptor (EGFR). The serine protease uPA and its high-affinity cell surface receptor uPAR play an important role in various physiological as well as pathological extracellular degradation processes, where cell migration is required, such as inflammatory responses and tumor invasion. Noelia Lino et al. showed that uPA has a key role during the central nervous system (CNS) development. In association with its receptor, it orchestrates both proteolytic and nonproteolytic events that govern the proper formation of neural networks.
The main steps in the production of this PLAU recombinant antibody include immunization; harvest of positive spleen cells; obtaining the antibody sequence by screening and sequencing; expression of the target antibody in mammalian cells; purification. The PLAU antibody was produced recombinantly and has many advantages: high reproducibility, specificity and scalability. And has been validated in ELISA, IHC.There are currently no reviews for this product.