Code | CSB-RA162005A0HU |
Size | US$210 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
The process for producing the PTH1R recombinant antibody involves four key steps: sequencing the gene that codes for the PTH1R monoclonal antibody, cloning this gene into a plasmid vector, introducing the recombinant vector into a host cell line, and purifying the resulting recombinant monoclonal antibody using affinity chromatography. The PTH1R monoclonal antibody originates from PTH1R antibody-producing hybridomas, and during its production, a synthesized peptide derived from human PTH1R is utilized as the immunogen. The PTH1R recombinant monoclonal antibody is highly recommended for use in both ELISA and WB applications to detect human PTH1R protein.
The PTH1R protein is a G protein-coupled receptor that is activated by parathyroid hormone (PTH). Its main function is to regulate calcium homeostasis in the body by controlling the release of calcium from bone, absorption of calcium from the gut, and reabsorption of calcium in the kidneys. When PTH binds to PTH1R, it stimulates the production of cAMP, which activates protein kinase A (PKA), resulting in the activation of various signaling pathways that regulate the activity of calcium channels and transporters. This ultimately leads to the release of calcium from bone into the bloodstream, and the reabsorption of calcium in the kidneys, while inhibiting calcium uptake in the gut. PTH1R is also involved in the development and maintenance of bone and the regulation of phosphate homeostasis.
There are currently no reviews for this product.