PTH1R

The gene PTH1R encodes the Parathyroid Hormone 1 Receptor (PTH1R), also known as the Parathyroid Hormone/Parathyroid Hormone-related Protein Receptor (PTH/PTHrP type 1 receptor). This receptor is a G protein-coupled receptor (GPCR) that plays a crucial role in regulating calcium and phosphorus homeostasis. PTH1R binds to parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP), leading to the activation of intracellular signaling pathways. These pathways include the GαS-adenylyl cyclase-cAMP-protein kinase A (PKA) pathway, which is essential for the regulation of blood calcium levels. PTH1R mutations are associated with various diseases, including Eiken syndrome, a rare condition characterized by delayed bone mineralization. The development of drugs targeting PTH1R is ongoing, with the aim of treating conditions such as hypoparathyroidism and osteoporosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PTH1R at 2 μg/ml can bind Anti-PTH1R recombinant antibody (CSB-RA018988MA1HU). The EC₅₀ is 0.7813-1.048 ng/mL.

PTH1R Recombinant Monoclonal Antibody (CSB-RA018988MA1HU)

Validated Data

The Binding Activity of Human PTH1R with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human PTH1R(CSB-MP018988HU) at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC₅₀ is 0.7813-1.048 ng/mL.

The Binding Activity of Rat Pth1r with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Pth1r（CSB-MP018988RA2） at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC₅₀ is 0.7384-1.203 ng/mL.

The Binding Activity of Macaca fascicularit PTH1R with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularit PTH1R(CSB-MP018988MOV4) at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC₅₀ is 1.072 to 1.403 ng/mL.

The following PTH1R reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PTH1R Antibodies

PTH1R Proteins

PTH1R Antibodies

PTH1R Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA040068	PTH1R Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA440946	PTH1R Antibody	Human	WB, IHC, ELISA
CSB-PA018988LA01HU	PTH1R Antibody	Human, Rat, Mouse	ELISA, WB
CSB-PA018988LB01HU	PTH1R Antibody, HRP conjugated	Human	ELISA
CSB-PA018988LC01HU	PTH1R Antibody, FITC conjugated	Human
CSB-PA018988LD01HU	PTH1R Antibody, Biotin conjugated	Human	ELISA
CSB-RA162005A0HU	PTH1R Recombinant Monoclonal Antibody	Human	ELISA, WB
CSB-RA018988MA1HU	PTH1R Recombinant Monoclonal Antibody	Human, Rat, Macaca fascicularis	ELISA

PTH1R Proteins

PTH1R Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-MP018987PI	Recombinant Pig Parathyroid hormone (PTH)	Mammalian cell
CSB-CF018988PI	Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	in vitro E.coli expression system
CSB-EP018988PI CSB-BP018988PI CSB-MP018988PI CSB-EP018988PI-B	Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)

Code	Product Name	Source
CSB-CF018988DKL	Recombinant Didelphis marsupialis virginiana Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	in vitro E.coli expression system
CSB-YP018988DKL1 CSB-EP018988DKL1 CSB-BP018988DKL1 CSB-MP018988DKL1 CSB-EP018988DKL1-B	Recombinant Didelphis marsupialis virginiana Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF630854BO	Recombinant Bovine Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	in vitro E.coli expression system
CSB-YP630854BO1 CSB-EP630854BO1 CSB-BP630854BO1 CSB-MP630854BO1 CSB-EP630854BO1-B	Recombinant Bovine Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF018988RA	Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r)	in vitro E.coli expression system
CSB-EP018988RA1 CSB-BP018988RA1 CSB-MP018988RA1 CSB-EP018988RA1-B	Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF018988MO	Recombinant Mouse Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r)	in vitro E.coli expression system
CSB-YP018988MO1 CSB-EP018988MO1 CSB-BP018988MO1 CSB-MP018988MO1 CSB-EP018988MO1-B	Recombinant Mouse Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-CF732722PYX	Recombinant Pongo abelii Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	in vitro E.coli expression system
CSB-YP732722PYX1 CSB-EP732722PYX1 CSB-BP732722PYX1 CSB-MP732722PYX1 CSB-EP732722PYX1-B	Recombinant Pongo abelii Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP866142DO1 CSB-EP866142DO1 CSB-BP866142DO1 CSB-MP866142DO1 CSB-EP866142DO1-B	Recombinant Dog Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTH1R Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-MP018988HU	Recombinant Human Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial (Active)	Mammalian cell

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PTH1R

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