PXN Antibody

Datasheet
Code CSB-RA019112A0HU
Size US$350
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Product Details

Uniprot No. P49023
Target Names PXN
Alternative Names FLJ16691 antibody; FLJ23042 antibody; Paired box protein Pax 1 antibody; PAX 1 antibody; PAX1 antibody; PAXI_HUMAN antibody; Paxillin alpha antibody; Paxillin antibody; PXN antibody; PXN protein antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human PXN
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Gene References into Functions
  1. Data suggest that FGFR3 with mutation found in patients with SADDAN (but not FGFR3 with mutation found in patients with TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II) PMID: 29242050
  2. overexpression of Paxillin significantly decreased tumor volume of colorectal cancer; miR-24 was overexpressed in natural killer cells and inhibited paxillin expression. PMID: 29494963
  3. XIST positively regulated PXN levels by sponging miR-137 in vitro and in vivo. Collectively, our study provided the evidence for the cross-talk between XIST, miR-137, and PXN, shedding light on the therapy for non-small cell lung cancer . PMID: 29337100
  4. we herein demonstrated that frequent overexpression of PXN in cervical cancer was associated with advanced tumor stage, poor differentiation and metastasis, and poor predictive outcomes PMID: 29318915
  5. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. PMID: 28954813
  6. we collected paraffin specimens from 85 GBM patients and evaluated the expression pattern of paxillin. Notably, we found that discernable paxillin signals were detected in 67 out of 85 samples. Given that leading edge is critical for cancer cell migration, we propose that NA treatment may be developed into a potential therapy for malignant glioma PMID: 28656206
  7. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions. PMID: 29021139
  8. REVIEW of the functions of paxillin in pathological conditions, particularly in cell migration PMID: 28214467
  9. This study showed that the PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy PMID: 27637748
  10. The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing paxillin expression through the alternative splicing of lncRNA-PXN-AS1. PMID: 28553938
  11. These data suggest that paxillin appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF or BME may be influenced by paxillin status, although this seems to be dependent on cell type PMID: 28739717
  12. The role of paxillin in the aging process of skin cells is reviewed. PMID: 27708212
  13. interactions between Cat-1 and its binding partner paxillin are necessary to ensure sufficient Akt activation so that cancer cells are able to grow under anchorage-independent conditions PMID: 28100775
  14. The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer. PMID: 27035282
  15. Results showed that the positive rate of PXN was significantly higher in the colorectal adenocarcinoma samples and correlated with TNM stage, distant metastasis and recurrence additionally to cetuximab resistance. PMID: 26530439
  16. blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin are significantly expressed in individual cases. PMID: 27068854
  17. These findings suggest that PXN expression has potential use as a novel biomarker of laryngeal squamous cell carcinoma patients and may serve as an independent predictive factor for prognosis. PMID: 26464671
  18. Mode of Action of Functionally Important Regions in the Intrinsically Disordered Paxillin PMID: 26928467
  19. Paxillin was expressed at significantly higher levels in colorectal cancer tissues and might serve as a potential prognostic indicator in patients with colorectal cancer PMID: 26159303
  20. these data suggested that miR-145 plays a pivotal role in colon cancer through inhibiting cell proliferation migration and invasion, and miR-145 may serve as a tumor suppressor by targeting paxillin gene. PMID: 25973017
  21. In colorectal cancers PXN was positively correlated with Bcl-2, pBcl-2-S87, and MMP2 expression. PXN promotes Bcl-2 phosphorylation at Serine 87 via ERK activation, increases xenograft tumor formation, and associates with poor patient outcome. PMID: 25826088
  22. Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer. PMID: 25323586
  23. Fascin-1 and paxillin were expressed in 58% and 43% of infiltrating duct carcinoma cases. There was a significant correlation between fascin-1 and paxillin expression and tumor grade, clinical stage, lymph-node metastasis grade, and HER2 expression. PMID: 26349603
  24. Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension. PMID: 25231004
  25. During early cell spreading, DLC1 is preferentially localized at the inner/mature adhesions whereas phosphorylated paxillin occupies the outer/nascent focal adhesions. In addition, DLC1 downregulates paxillin turnover PMID: 25448629
  26. The expression levels of Wnt5a, p-JNK1 and p-paxillin in tumor tissues were correlated with each other. PMID: 24395444
  27. LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase PMID: 25795725
  28. This chapter outlines recent advances in understanding how paxillin regulates both steroid and growth factor signaling, focusing on the conserved nature of its actions from a frog germ cell to a human cancer cell. PMID: 25182764
  29. Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells. PMID: 24096476
  30. High PXN expression is associated with oral cavity squamous cell carcinoma. PMID: 24894864
  31. paxillin may promote cell proliferation and inhibit apoptosis in SW480 cells. Paxillin may be a potential metastasis predictor, and an independent prognosis factor of recurrence. PMID: 24451945
  32. MEKK2 induces paxillin ubiquitylation in breast cancer cells and this function requires both paxillin LD1 motif and MEKK2 kinase activity. PMID: 25190348
  33. Paxillin knockdown increases capillary endothelial cell migration and invasiveness, and thereby enhances microvessel ingrowth, by suppressing NRP2 expression. PMID: 24522185
  34. Through HDAC6-dependent regulation of the microtubule cytoskeleton, paxillin regulates both Golgi organelle integrity and polarized cell invasion. PMID: 25070956
  35. PXN plays an important role in tumor progression and may be used as a potential prognostic indicator in gastric cancer PMID: 24180516
  36. Future studies investigating these hypotheses on TG-2-paxillin relationships are necessary in order to address this fundamental process in cell matrix adhesion signaling. PMID: 24193434
  37. The data suggests that mutant PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression. PMID: 23792636
  38. In aneuploid tumors, EZH2 expression and paxillin expression correlate with more aggressive phenotype of breast cancer. PMID: 24344012
  39. ezrin and paxillin may have roles in aggressive tumor features and invasiveness in urothelial bladder tumors PMID: 21868260
  40. The paxillin plays vital roles in cell motility through regulation of focal adhesion dynamics. PMID: 22481092
  41. Lysophosphatidic acid (LPA) induces both time and dose-dependent tyrosine phosphorylation of paxillin and focal adhesion kinase. PMID: 24061591
  42. Paxillin signaling contributed to tumor growth and vasculogenic mimicry of gallbladder carcinomas. PMID: 23588386
  43. Mutation of paxillin serine 250 prevents its phosphorylation by SLK in vitro and results in impaired migration in vivo as evidenced by an accumulation of phospho-FAK-Tyr397 and altered FA turnover rates. PMID: 23128389
  44. Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin. PMID: 23389630
  45. overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in colorectal cancer patients. PMID: 23275153
  46. Paxillin is critical for integrating physical cues from the ECM with chemical motility signals by spatially constraining where cells form motile processes, and thereby regulates directional migration. PMID: 23076140
  47. Fascin-1, ezrin and paxillin contribute to the malignant progression and are predictors of clinical prognosis in laryngeal squamous cell carcinoma. PMID: 23209815
  48. Paxillin is a new regulator protein of pulmonary arterial smooth muscle cell growth. PMID: 22959909
  49. phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin trafficking, and cellular protrusive activity are regulated. PMID: 22893698
  50. Findings suggest that the MLK3-JNK-paxillin signaling axis may represent a potential prognostic marker in breast cancer metastasis. PMID: 22700880
  51. proper localization of beta-parvin to focal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin is important for early targeting of beta-parvin. PMID: 22869380
  52. cell adhesion-dependent Ser-85 phosphorylation of paxillin is important for its interaction with talin and regulation of dynamic FAs and cell migration. PMID: 22761432
  53. analysis of paxillin domains interacting with beta-catenin PMID: 22728435
  54. paxillin is a liaison between extranuclear MAPK signaling and nuclear transcription in response to androgens and growth factors PMID: 22684108
  55. Paxillin integrates physical and chemical motility signals by spatially constraining where cells will form motile processes, and thereby regulates directional migration. PMID: 22194823
  56. these results suggest that paxillin is required for the early phase of EC orientation in response to cyclic stretching by scaffolding for accumulation of focal adhesion proteins. PMID: 22293201
  57. paxillin may play an essential role in the progression of colorectal cancer. PMID: 21940355
  58. We propose paxillin as a novel cellular target for converging H. pylori-induced EGFR, FAK/Src, and PI3K/Akt signaling to regulate cytoskeletal reorganization and IL-8 production in part, thus contributing to the H. pylori-induced diseases. PMID: 21757638
  59. Down-regulation of paxillin is associated with autism. PMID: 21703394
  60. When myosin II contractility was inhibited, the k(off) values for all three proteins changed rapidly, in a highly protein-specific manner: dissociation of vinculin from FAs was facilitated, whereas dissociation of paxillin and zyxin was attenuated. PMID: 21486952
  61. Talin-1 and vinculin negatively affect tyrosine phosphorylation of paxillin, a novel positive regulator of HIV-1 infection, and impose an early block to infection by distinct retroviruses. PMID: 21763488
  62. the crystal structures of CCM3 in complex with three different leucine-aspartate repeat (LD) motifs (LD1, LD2, and LD4) from the scaffolding protein paxillin PMID: 21632544
  63. Paxillin is a key regulator of 3D adhesion assembly, stabilization and disassembly. PMID: 21148292
  64. The expression of paxillin showed no correlation with estrogen/progesterone and HER2 expression nor with tumor grade and stage in breast carcinomas. PMID: 21614903
  65. In contrast to a previous report, this study showed that PXN mutation was absent in lung cancers and other common solid cancers, suggesting that PXN mutation may not play a principal role in solid cancer development. PMID: 21617717
  66. a novel role for calpain-mediated proteolysis of paxillin as a negative regulator of focal adhesion dynamics and migration that may function to limit cancer cell invasion. PMID: 21270128
  67. The expression of paxillin may play an important role in human breast cancer metastasis and adhesion. PMID: 20369478
  68. Differential requirement of adapter proteins paxillin and T cell linker (LAT) for responses to beta2 integrin (LFA-1) and CD16 are important for different signaling complex assemblies of signaling molecules to determine functional outcomes. PMID: 21270398
  69. New results confirmed that human cytomegalovirus entry into target monocytes was significantly reduced in cells deficient in paxillin expression or the integrin/Src/paxillin signaling pathway. PMID: 21084488
  70. paxillin expression upregulated in SACC. High expression of paxillin correlated with more advanced stage and metastasis in SACC. paxillin is possibl disease marker in advanced SACC and SACC with distant metastasis. Possible value as therapeutic target PMID: 20136697
  71. Expressed in most neuroendocrine tumors of lung. Significant correlation between PAX5 and paxillin was detected in SCLCs and large cell neuroendocrine carcinomas but not in carcinoid tumors. PMID: 21043826
  72. Data describe the role of the IGF-IR in bladder cancer and show that it required the activation of the Akt and MAPK pathways as well as IGF-I-induced Akt- and MAPK-dependent phosphorylation of paxillin. PMID: 20395438
  73. paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals. PMID: 20628053
  74. cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor PMID: 20525696
  75. Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88). PMID: 20133777
  76. Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation. PMID: 20127017
  77. a small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation PMID: 20097761
  78. leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling. PMID: 19917054
  79. Paxillin silencing by RNA interference inhibits the cell invasiveness stimulated by fibronectin. Paxillin is a key factor in the fibronectin-stimulated invasiveness of AGS cells. PMID: 20210243
  80. MPS-1 reduces paxillin mRNA and protein levels in head-and-neck squamous-cell carcinoma cells both in vitro and in vivo. PMID: 19642098
  81. expression in conventional renal cell carcinomas (RCCs), papillary RCCs, chromophobe RCCs, collecting duct carcinomas, oncocytomas; role in signal transductions as a focal adhesion between tumor cells and the ECM in tumors with collecting duct phenotypes PMID: 11759057
  82. Tyrosine phosphorylation of PXN regulates localization and downstream signaling with profound effects on cell movement. PMID: 11779709
  83. Binding of cytoskeletal paxillin to the C-terminal of Pyk2 in cultured human umbilical vein endothelial cells is phosphorylation-independent and is not affected by acute exposure to thrombin. PMID: 11820787
  84. Amino acid substitutions at relevant serine residues in urokinase prevents paxillin redistribution in MCF-7 cells. PMID: 11928806
  85. Paxillin binding to the alpha 4 integrin tail is required for both efficient communication between integrins alpha 4 beta 1 and alpha L beta 2 and for direct integrin alpha 4 beta 1-dependent T cell migration. PMID: 12794117
  86. Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of this protein. PMID: 12837751
  87. phosphorylation of paxillin by JNK seems essential for maintaining the labile adhesions required for rapid cell migration PMID: 12853963
  88. interaction of bcl-2 with paxillin plays an important role during nephrogenesis PMID: 14699151
  89. Data show that phosphorylation of paxillin is involved in NGF-induced neurite extension of PC-12 cells, probably through regulating focal adhesion organization. PMID: 14970194
  90. Lysophosphatidic acid induces Rho activation and consequent tyrosine phosphorylation of paxillin in human corneal epithelial cellss. Likely contributes to promotion of corneal epithelial migration by this agent. PMID: 15175910
  91. early spreading responses to HGF may partly relate to increased paxillin availability for incorporation into, and turnover within, dynamic cytoskeletal/membrane complexes whose rapid and transient adhesion to the matrix drives migration. PMID: 15191880
  92. chemoattractant stimulation induces paxillin association with alpha4 integrins, particularly in leukocytes PMID: 15242880
  93. paxillin tyrosine 31 and 118 phosphorylation controls polarization and motility of lymphoid cells and is PMA-sensitive PMID: 15252114
  94. Myocilin impaired focal adhesion formation and specifically blocked the incorporation of paxillin, but not vinculin, into focal adhesions. PMID: 15652337
  95. Angiotensin II mediates an increase in focal adhesion kinase and paxillin phosphorylation and induces human umbilical vein endothelial cells migration through signal transduction pathways PMID: 15652490
  96. Expression of paxillin and syndecan-1 in hepatocellular carcinoma(HCC) may affect its invasive and metastatic ability. May be converse correlation between expression of paxillin and syndecan-1 protein in HCC. PMID: 15770719
  97. Caco-2 migration on collagen IV is regulated by both p130cas and paxillin but Src phosphorylation of p130cas is more important for this process PMID: 15817476
  98. overexpression of paxillin synergistically contribute to the high metastatic potential of human osteosarcoma through the hyperphosphorylation of paxillin PMID: 15870699
  99. p130Cas and paxillin function as effectors of GD3-mediated signaling, leading to such malignant properties as rapid cell growth and invasion in melanoma cells PMID: 16040804
  100. proteomic analysis of paxillin post-translational modifications and interacting proteins by mass spectrometry PMID: 16212439

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Subcellular Location Cytoplasm, cytoskeleton, Cell junction, focal adhesion, Cytoplasm, cell cortex
Protein Families Paxillin family
Database Links

HGNC: 9718

OMIM: 602505

KEGG: hsa:5829

STRING: 9606.ENSP00000228307

UniGene: Hs.446336

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