Code | CSB-RA013481A231phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
Phospho-MAPT (T231) antibody CSB-RA013481A231phHU is a recombinant monoclonal antibody produced from the expression of the plasmids that were constructed by the pT231-MAPT monoclonal antibody (generated from animals with the synthesized peptide derived from human phospho-MAPT (T231) immunization) DNA sequence in cell lines. The phospho-MAPT (T231) antibody was purified through affinity- chromatography method. It is a rabbit IgG antibody. It is recommended for the detection of human MAPT phosphorylated at T231 in ELISA and WB analyses.
Tau's ability to bind and assemble microtubules (MTs) is regulated by phosphorylation and other posttranslational modifications. Tau phosphorylation reduces its affinity for MTs and eliminates its capacity to drive MT polymerization in general, but the specific consequences vary depending on the number and position of phosphorylation sites. Phosphorylated T231 selectively forms a salt bridge with R230 that can compete with the buildup of intermolecular salt bridges to tubulin.
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