Phospho-MYC (T58+S62) Antibody

^Datasheet

Code	CSB-RA015270A58-62phHU
Size	US$350
Uniprot No.	P01106
Image	Western Blot Positive WB detected in：HepG2 whole cell lysate(treated with EGF or not) All lanes：Phospho-MYC antibody at 0.99μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 57 KDa Observed band size: 57 KDa
Immunogen	A synthesized peptide derived from Human Phospho-MYC (T58+S62)
Species Reactivity	Human
Tested Applications	ELISA, WB; Recommended dilution: WB:1:500-1:5000
Relevance	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
Isotype	Rabbit IgG
Clonality	Monoclonal
Alias	Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Immunogen Species	Homo sapiens (Human)
Protocols	ELISA Protocol Western Blotting(WB) Protocol
Research Area	Epigenetics and Nuclear Signaling
Gene Names	MYC
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis
Involvement in disease	Burkitt lymphoma (BL)
Subcellular Location	Nucleus, nucleoplasm, Nucleus, nucleolus
Database Links	HGNC: 7553 OMIM: 113970 KEGG: hsa:4609 STRING: 9606.ENSP00000367207 UniGene: Hs.202453
Pathway	ErbB signaling pathway Hippo signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway TGF-beta signaling pathway Wnt signaling pathway Cell cycle Cellular senescence Signaling pathways regulating pluripotency of stem cells

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