Code | CSB-RA015270A58-62phHU |
Size | US$210 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
CUSABIO engineered a vector by inserting a sequence encoding the phospho-MYC (T58+S62) monoclonal antibody and then transfected this vector into the cell line for in vitro expression. The monoclonal antibody was generated from immunized animals with the synthesized peptide derived from phosphorylated human MYC at Thr 58 and Ser 62 residues. The collected tissue culture supernatant (TCS) underwent affinity-chromatography purification to get the recombinant phospho-MYC (T58+S62) monoclonal antibody. This anti-phospho-MYC (T58+S62) antibody is a rabbit IgG. It is suitable for the detection of the human phospho-MYC (T58+S62) in ELISA and WB.
The c-Myc oncoprotein is a pleiotropic transcription factor that regulates a variety of cellular processes, including cell proliferation, cell growth, and cell differentiation, as well as genome stability and cell death pathways. Most human cancers constitutively highly express c-Myc, and high c-Myc expression in animal models can induce carcinogenesis. Conserved Thr 58 and Ser 62 phosphorylation sites that help regulate c-Myc protein stability affect c-Myc expression, and altered ratios of Thr 58 and Ser 62 phosphorylation have been reported in human cancer.
There are currently no reviews for this product.