Code | CSB-RA784971A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The RBP4 recombinant monoclonal antibody is useful for detecting human RBP4 protein in ELISA and IHC applications. It is produced using recombinant DNA technology, whereby the gene encoding for the RBP4 monoclonal antibody is synthesized after sequencing the cDNA of the RBP4 antibody-producing hybridomas. These hybridomas are formed by fusing myeloma cells with B cells that are isolated from an animal that has been immunized with a synthesized peptide derived from human RBP4. The synthesized gene is then cloned into a vector and transfected into cells for cultivation. After that, the resulting RBP4 recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
The RBP4 protein is a carrier protein that transports retinol (vitamin A) in the blood. It is synthesized and secreted by the liver and adipose tissue and plays an important role in regulating whole-body vitamin A homeostasis. In addition to its role in transporting retinol, RBP4 has been implicated in the regulation of glucose metabolism and insulin resistance. Specifically, high levels of RBP4 have been associated with insulin resistance and type 2 diabetes in human and animal models.
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