RHEB Recombinant Monoclonal Antibody

1. Cycling between the inactive GDP- and the active GTP-bound state modulates the backbone dynamics of a C-terminal truncated form, RhebDeltaCT, which is suggested to influence its interactions. We further investigated the interactions between RhebDeltaCT and the proposed Rheb-binding domain of the regulatory protein FKBP38. PMID: 29194576
2. Rheb transcription is regulated by direct Notch1 binding to the Rheb promoter. Rheb expression in the angiomyolipoma and lymphangioleiomyomatosis cells. PMID: 29184052
3. RHEB Y35N expressing cells undergo cancer transformation due to decreased interaction between RHEB and BRAF resulting in overactive RAF/MEK/ERK signaling. Taken together with the previously established function of RHEB to activate mTORC1 signaling, it appears that RHEB performs a dual function; one is to suppress the RAF/MEK/ERK signaling and the other is to activate mTORC1 signaling. PMID: 29320991
4. SNPs of mTORC1-related genes individually or jointly contribute to colorectal cancer susceptibility in Chinese. PMID: 29996312
5. Results identified Rheb as a critical mediator of EP3 expression in cells with mTORC1 hyperactivation. PMID: 28710231
6. RHEB maintained the innate characteristics of chondrocytes by regulating senescence, dedifferentiation and oxidative stress, leading to the upregulation of COL2 expression via SOX9 and the downregulation of p27 expression via MCL1. PMID: 27061379
7. 3.0 angstrom cryo-electron microscopy structure of mTORC1 and the 3.4 angstrom Xray structure of activated RHEB-mTORC1 PMID: 29236692
8. The mTOR activator gene RHEB is an intellectual disability gene that is associated with megalencephaly when mutated. PMID: 29051493
9. Cellular treatment with AG2037, an inhibitor of the purine biosynthetic enzyme GARFT, profoundly inhibits mTORC1 activity via a reduction in the level of GTP-bound Rheb, an obligate upstream activator of mTORC1, because of a reduction in intracellular guanine nucleotides. PMID: 28658616
10. FADD interference down-regulated Rheb expression and repressed mTORC1 activity in breast cancer cell lines. The autophagy was induced by FADD deficiency in MCF7 or MDA-231 cells but rescued by recovering Rheb expression. PMID: 27013580
11. Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells. PMID: 27034171
12. activation of mTOR signalling via RHEB over-expression inhibited the starvation-induced autophagy but did not affect trafficking of tf-Amyloid precursor protein (APP). These results show tf-APP can be used to determine how APP is trafficked through the lysosomal system of the cell. PMID: 28641977
13. Data suggest DNM2/RRAGB- (or DNM2/RRAGC-)dependent endocytosis of extracellular amino acids (AAs) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB = Ras homolog enriched in brain; DNM2 = dynamin II; RRAG = Ras-related GTP binding protein) PMID: 28808055
14. By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC. Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1. PMID: 26742086
15. Data show that Rheb/p27 axis induces autophagy-dependent cancer cell survival under stress conditions. PMID: 25594310
16. Mutations in the TSC2-RHEB-mTOR signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell. PMID: 26255626
17. Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H) transduction of dopaminergic neurons PMID: 25799580
18. In TSC2-deficient angiomyolipoma patient cells, IRF7 is a pivotal factor in the Rheb/mTOR pathway. PMID: 25476905
19. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) PMID: 25422319
20. In vitro data indicated that miR-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of Pseudomonas aeruginosa by targeting Rheb (Ras homolog enriched in brain). PMID: 24403554
21. Data indicate that Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR) signaling. PMID: 24648513
22. study defines Rheb as a novel physiological regulator of BACE1 levels and Abeta generation, and the Rheb-BACE1 circuitry may have a role in brain biology and disease. PMID: 24368770
23. Maturation of endosomes into lysosomes may be required to assure a continuous supply of GTP-bound Rheb for mTORC1 activation, which may help to drive the maturation process PMID: 23863162
24. The propose models of membrane-dependent signal regulation by Rheb that shed light on previously unexplained in vivo properties of this GTPase. PMID: 23409921
25. In a human embryonic brain cDNA library mTOR-activating GTPase Rheb is screened as an interacting protein of the NMDAR subunit NR3A. PMID: 21135540
26. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. PMID: 21784859
27. The activating transcription factor (ATF)6alpha/Rheb pathway is altered in Huntington's disease, as the decrease in ATF6alpha processing is accompanied by a decrease in the accumulation of Rheb. PMID: 20732420
28. Adenoassociated virus-mediated transduction of substantia nigra dopaminergic neurons with constitutively active forms of kinase Akt and Ras homolog enriched in brain (Rheb) induces regrowth of axons after they have been destroyed by neurotoxin lesion. PMID: 21437936
29. TSC1, TSC2 and Rheb function independently of TORC1 in tuberous sclerosis complex.[Review] PMID: 21412983
30. Rheb inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 PMID: 21336308
31. Rheb controls proliferation of TSC2-deficient cells by a mechanism that involves regulation of AMPK and p27, and that Rheb is a potential target for TSC/LAM therapy. PMID: 20818424
32. Ras homolog enriched in brain (Rheb) enhances apoptotic signaling PMID: 20685651
33. results suggest a novel regulatory mechanism for mTORC1 in which the cAMP-determined dynamic interaction between Rheb and PDE4D provides a key, unique regulatory event, and propose a new role for PDE4 as a molecular transducer for cAMP signaling. PMID: 20837708
34. Results suggest that Rheb is a critical target for farnesyltransferase inhibitor therapy in non-small cell lung cancer cells. PMID: 20554106
35. integrity of late endosomes is essential for amino acid- and insulin-stimulated mTORC1 signaling and blocking the early/late endosomal conversion prevents mTOR from interacting with Rheb in the late endosomal compartment PMID: 20053679
36. Findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb and mTORC1 and promotion of a differentiated vascular smooth muscle cell phenotype. PMID: 20375271
37. Rheb potentiates proliferation of prostate cancer cells PMID: 20127734
38. RHEB is an MTOR activator that facilitates multistage carcinogenesis through induction of multiple oncogenic mechanisms PMID: 20388784
39. Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL PMID: 20048149
40. Data inidicate that FTS could be a promising treatment for Rheb- and mTOR-dependent cancers. PMID: 19838215
41. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner PMID: 12842888
42. Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth PMID: 12869586
43. Rheb has a role in regulation of B-Raf kinase activity along with tuberin but without involvement of mTOR PMID: 15150271
44. To investigate the function of TSC2 and Rheb in mTOR signaling, we analyzed the TSC2-stimulated Rheb GTPase activity. PMID: 15340059
45. The GTPase domain of human Rheb (hRheb) has been recombinantly expressed in Escherichia coli, purified and cocrystallized in complexes with GDP, GTP and GppNHp. PMID: 15388940
46. Rheb forms a new group of the Ras/Rap subfamily and uses a novel GTP hydrolysis mechanism that utilizes Asn1643 of the tuberous sclerosis complex 2 GTPase-activating protein domain instead of Gln64 of Rheb as the catalytic residue PMID: 15728574
47. results suggest that Rheb regulates endocytic trafficking pathway independent of the previously identified mTOR pathway. PMID: 15809346
48. The target of rapamycin (TOR) complex 1 is a direct target of Rheb-GTP, whose binding enables activation of the TOR kinase. PMID: 15854902
49. binding of Rheb to endogenous and recombinant mTOR is reversibly inhibited by withdrawal of all extracellular amino acids or just leucine PMID: 15878852
50. Data show that the farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. PMID: 16006564

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HGNC: 10011

OMIM: 601293

KEGG: hsa:6009

STRING: 9606.ENSP00000262187

UniGene: Hs.283521