RPS6KB2 Recombinant Monoclonal Antibody

1. Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency PMID: 28301598
2. We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery. PMID: 27407113
3. discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer PMID: 24469061
4. Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. PMID: 25124033
5. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer. PMID: 24131622
6. The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism. PMID: 22955948
7. S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis PMID: 23393338
8. Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer. PMID: 21427355
9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
10. p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells PMID: 12176053
11. regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation PMID: 12529391
12. the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells. PMID: 12818373
13. These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation. PMID: 12875979
14. p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner. PMID: 14729629
15. S6K2 is active throughout the cell cycle with higher activity in G2 and M phases. PMID: 17786541

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HGNC: 10437

OMIM: 608939

KEGG: hsa:6199

STRING: 9606.ENSP00000308413

UniGene: Hs.534345