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The recombinant SSTR2 antibody was prepared by obtaining the antibody genes, cloning the genes into a plasma vector to construct vector clone, transfecting the vector clone into a mammalian cell line for transient expression, and purifying the antibody by affinity-chromatography. This recombinant SSTR2 antibody has been verified to detect the SSTR2 protein from Human in the ELISA, IHC.
Upon activation by somatostatin or its synthetic analogs, SSTR2 mediates multiple physiological effects, such as regulating the physiologic secretion of insulin, glucagon, thyroid-stimulating hormone, and growth hormone (GH), as well as protecting retina nerves and modulating neuronal excitability. SSTR2 also takes part in cell cycling, angiogenesis, apoptosis, and growth factor signaling. Evidence has demonstrated that SSTR2 is overexpressed in neuroendocrine neoplasms and is remarkably methylated in colorectal cancer as well as correlates to tumorigenesis in gastric and breast cancer.
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