Recombinant Human Somatostatin receptor type 2(SSTR2)

Code CSB-CF022725HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P30874
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names SSTR2
Protein Names Recommended name: Somatostatin receptor type 2 Short name= SS-2-R Short name= SS2-R Short name= SS2R Alternative name(s): SRIF-1
Expression Region 1-369
Tag Info N-terminal 10xHis-tagged
Protein Description Full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Subcellular Location Cell membrane, Multi-pass membrane protein, Cytoplasm
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the
Database Links

HGNC: 11331

OMIM: 182452

KEGG: hsa:6752

STRING: 9606.ENSP00000350198

UniGene: Hs.514451

Pathway cAMP signaling pathway

Related Products

SSTR2 Antibodies

SSTR2 Antibodies for Homo sapiens (Human)

SSTR2 Antibodies for Human

SSTR2 Proteins

SSTR2 Proteins for Homo sapiens (Human)

Most popular with customers


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 CUSABIO TECHNOLOGY LLC All Rights Reserved.