Code | CSB-RA786226A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
FC | 1:20-1:200 |
IP | 1:200-1:1000 |
TRAF2 is an important adaptor protein that transduces signals after ligating to certain receptors including those binding TNF and is also an E3 ubiquitin ligase. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. Studies of TRAF2-deficient mice showed that TRAF2 plays an essential role in mediating cell survival, normal adaptive immune responses, and lymphocyte homeostasis. TRAF2 promotes survival, proliferation, and metastasis of tumor cells through the NF-κB pathway by directly interacting with various TNF receptors.
Compared with the polyclonal and monoclonal antibodies of TRAF2, this TRAF2 recombinant antibody has the features of increased reproducibility and control, animal-free technology, high degree of monovalency, high batch-to-batch consistency, easier isotype conversion, etc. And it has been validated in ELISA, WB, IHC, FC, IP.There are currently no reviews for this product.