Code | CSB-RA233609A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
The TXN recombinant monoclonal antibody is produced using recombinant DNA technology and is recommended for detecting human TXN protein in ELISA and WB applications. To prepare this antibody, the gene coding for the TXN monoclonal antibody is synthesized by sequencing the cDNA of TXN antibody-producing hybridomas. These hybridomas are created by fusing myeloma cells and B cells isolated from an animal that has been immunized with a synthesized peptide derived from human TRX1. After cloning the synthesized gene into a vector, it is transfected into cells for cultivation. Finally, the resulting TXN recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
The TXN (thioredoxin) protein, also called TRX1, is a small redox protein that is involved in multiple cellular processes, including cell growth and differentiation, oxidative stress response, and regulation of transcription factors. Its main function is to maintain a reduced intracellular environment by reducing disulfide bonds in other proteins. It has also been implicated in regulating apoptosis, cell cycle progression, and immune response. It can also function as a cofactor for some proteins involved in DNA repair and nucleotide excision repair.
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