ZG16B Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA836195MA1HU
Size	US$210
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Image	The Binding Activity of Human ZG16B with Anti-ZG16B recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B (CSB-MP836195HU) at 2 μg/mL can bind Anti-ZG16B recombinant antibody, the EC₅₀ is 24.13-46.04 ng/mL. The Binding Activity of Macaca fascicularis ZG16B with Anti-ZG16B recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B (CSB-MP4727MOV) at 2 μg/mL can bind Anti-ZG16B recombinant antibody , the EC₅₀ is 20.15-28.98 ng/mL.
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Target Background

Product Details

Uniprot No.

Q96DA0

Target Names

ZG16B

Alternative Names

ZG16B; Zymogen granule protein 16 homolog B; UNQ773/PRO1567

Species Reactivity

Human, Macaca fascicularis

Immunogen

Recombinant Human ZG16B protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

6E5

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO meticulously created the ZG16B recombinant monoclonal antibody through a carefully executed process. Initially, B cells were removed from the spleen of an immunized animal, with the recombinant human ZG16B protein serving as the immunogen. Following that, RNA extraction from the B cells and reverse transcription of RNA was performed to obtain cDNA. Using the cDNA as a template, the gene encoding the ZG16B antibody was amplified with a degenerate primer and inserted into a vector, which was then introduced into host cells via transfection to facilitate efficient antibody expression. The ZG16B recombinant monoclonal antibodies were harvested from the cell culture supernatant and purified using affinity chromatography. This antibody is recommended for the detection of human ZG16B protein in ELISA.

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Target Background

Gene References into Functions

we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID: 27322081
Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID: 28988106
Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID: 27706833
High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID: 26684804
PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID: 26336989
constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID: 25727013
PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID: 25079514
PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID: 23677445
new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID: 22907431
activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID: 22640743
PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID: 21464589
PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID: 21196815
Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID: 20858015
the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID: 20802527
Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID: 19784070
Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID: 16954406
pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID: 19302292

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Subcellular Location

Secreted.

Protein Families

Jacalin lectin family

Database Links

HGNC: 30456

KEGG: hsa:124220

STRING: 9606.ENSP00000371715

UniGene: Hs.105887

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Related pathways

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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