Recombinant Rat Intercellular adhesion molecule 1(Icam1)

Code CSB-CF010949RA
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Icam1
Uniprot No. Q00238
Alternative Names Icam1; Icam-1; Intercellular adhesion molecule 1; ICAM-1; CD antigen CD54
Species Rattus norvegicus (Rat)
Expression Region 28-545
Target Protein Sequence QVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Gene References into Functions
  1. The results suggest that ICAM-1 may play a critical role in bladder inflammation in severe non-bacterial cystitis and may be used as a novel therapeutic target in non-bacterial bladder inflammation such as bladder pain syndrome/interstitial cystitis. PMID: 27782122
  2. Pro-atherogenic effects of aldosterone are mediated by increased ICAM-1 expression, through transcriptional regulation by endothelial MR. PMID: 28089144
  3. Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression. PMID: 27525872
  4. MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway. PMID: 27889748
  5. The results of this study showed that ICAM-1 up regulation in both sexs rats with aneurysmal subarachnoid hemorrhage. PMID: 26923576
  6. intercellular adhesion molecule-1 has a role in the restructuring of the blood-testis barrier during spermatogenesis [review] PMID: 26419651
  7. ICAM-1 induction in vascular endothelium and leukocyte adhesion to vascular endothelium is decreased in NSun2 knock-out rats. PMID: 26838785
  8. ICAM-1 protein expression in the yellow wine (0.5% -1.5%) groups were significantly different. Yellow wine decreases ICAM-1 protein expression. PMID: 26853250
  9. PilE4:ICAM-1 interaction unfolded here may provide a new perspective on molecules involved in the adhesion of extracellular form of Francisella to endothelial cells. PMID: 25769821
  10. findings reveal a novel function of ICAM-1 in osteogenesis and suggest a new molecular target to improve bone regeneration and repair in inflammatory microenvironments. PMID: 24702024
  11. analysis of the role of Txnip, ICAM-1, and NOX2 expression in diabetes-induced endothelial dysfunctions with curcumin PMID: 25054130
  12. No correlation was found between ICAM1 levels and microvascular or macrovascular dysfunction in adjuvant-induced arthritis. PMID: 25708190
  13. Hesperetin-7-O-glucuronide decreased hydrogen peroxide-induced intracellular adhesion molecule-1 and monocyte chemoattractant protein-1 mRNA expression in rat aortic endothelial cells. PMID: 23831969
  14. Exogenously applied caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules. PMID: 24043249
  15. Data illustrate the existence of a unique mechanism in the mammalian testis where ICAM-1 can either positively or negatively regulate blood-testis barrier function. PMID: 22976294
  16. Simvastatin attenuates lung injury induced by ischemia-reperfusion of the hind limb in rats by suppressing the activation of NF-kappaB p65 and subsequent accumulation of neutrophils mediated by ICAM-1. PMID: 21764683
  17. Intercellular adhesion molecule-1 blockade attenuates ischemia/reperfusion injury (IRI) via reduction of leukocyte-endothelial interactions and improvement of capillary perfusion emphasizing its central role during IRI in pancreas transplantation PMID: 22617707
  18. Infection with Japanese encephalitis virus elicits elevated production of intercellular adhesion molecule-1 in brain. PMID: 22845610
  19. Repeated high + Gz exposures could injure cardiovascular endothelium of rat and increase ICAM-1 expression. PMID: 21180061
  20. renal expression increased in spontaneously hypertensive rats with renal damage PMID: 22681549
  21. Melatonin protected lung tissue from acute injury by scavenging free radicals and inhibiting the expression of ICAM-1. PMID: 21158154
  22. Hydrogen sulfide reduced the expressions of NFKB and ICAM1 in pulmonary tissue of rats with acute lung injury. PMID: 22333058
  23. A cholesterol diet plays a role in the expression of ICAM-1 but not in that of VCAM-1 in the rat aorta. The expression of ICAM-1 in the aorta regresses after the withdrawal of a cholesterol-rich diet. PMID: 22351665
  24. The freezing/thawing of vascular endothelial cells can elicit an increase in ICAM-1 expression on the cell surface. PMID: 21162227
  25. Vaspin inhibits TNF-alpha-induced expression of ICAM-1 via preventing the reactive oxygen species generation and subsequent activation of NF-kappaB and PKCtheta;. PMID: 21683791
  26. Data suggest that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. PMID: 21860531
  27. ICAM1 up-regulation at the time of implantation is under the control of progesterone, and is not dependent on cytokine release from the blastocyst or in semen PMID: 21448983
  28. Proteolytic cleavage of the extracellular domain of ICAM-1 and accumulation in kidney glomeruli may play a role in the renal involvement of inflammation. PMID: 21464573
  29. a signaling pathway involving aldose reductase, JNK, IKK, and NF-kappaB is required for ICAM-1 induction in ECs exposed to BFT, and may be involved in the leukocyte-adhesion cascade following infection with ETBF. PMID: 21724992
  30. Aging may upregulate lung MCP-1 and ICAM-1 expressions and enhance LPS-induced increments of MCP-1 and ICAM-1 expressions to exacerbate pulmonary inflammation in rats. PMID: 20335145
  31. Intercellular adhesion molecule 1 (ICAM-1) and E-selectin was down-regulated exclusively in mesenchymal stem cells /mycophenolate mofetil -treated grafts, indicating that MSC together with MMF interfere with endothelial activation PMID: 21194567
  32. Activation of the cholinergic anti-inflammatory pathway can protect the lung against ventilator-induced lung injury by suppressing IL-8 and ICAM-1 expression. PMID: 20663304
  33. in the early phase of acute oral mucosal graft-versus-host disease,the induction of ICAM-1 expression on keratinocytes leads to the migration of CD8+ cells into the epithelium PMID: 21472687
  34. Isoflurane up-regulated the expression of ICAM-1 in LPS-induced rat lung microvascular endothelial cells but sevoflurane and desflurane down-regulated expression. PMID: 20936719
  35. Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. PMID: 21071702
  36. The expression of ICAM-1 and MUC5AC in lung tissue were both significantly higher in allergic rhinitis than that in control group. PMID: 16229173
  37. Salvia significantly reduces the expressions of NF-kappaB and ICAM-1 in ischemia-reperfusion hepatic tissue. PMID: 20979835
  38. during localized inflammatory pain, peripheral sensory and sympathetic nerve fibers augment the expression of vascular endothelial ICAM-1 PMID: 20600813
  39. Baicalin can decrease the contents of TNF-alpha and sICAM-1, and alleviate inflammation in lung tissues of rats infected with Pneumocystis carinii. PMID: 19856505
  40. By up-regulating the expression of ICAM-1 and MMP-9 protein and mRNA in pulmonary vascular wall, cigarette smoke exposure mediated pulmonary vascular inflammation and remodeling. PMID: 20079284
  41. Transferring NF-kappa B p65 antisense oligonucleotides into hepatic stellate cells weakened the expression of ICAM-1 and TGF beta 1 mRNA and the protein induced by TNF alpha. PMID: 18983774
  42. ICAM-1 mRNA analysis may be useful for estimation of early wound age because of its time-related expression after contusion in skin and muscle. PMID: 19241963
  43. Elevated expression of ET-1, iNOS, COX-2, and ICAM-1 occurred in the cortex of middle cerebral artery occlusion (MCAO) model rats. PMID: 20083630
  44. Curcumin can ameliorate cerebral pathological changes in the event of ischemia-reperfusion injury by suppressing the expressions of NF-kappaB and ICAM-1. PMID: 19726347
  45. Leptin induces an inflammatory phenotype in lean Wistar rats that includes increased production of ICAM-1, MCP-1, and IL-6 by hepatocytes PMID: 20150963
  46. The expression of ICAM-1 mRNA peaked at 6 h in skeletal muscle after contusion. PMID: 19697769
  47. retinal expression induced by VEGF PMID: 11839570
  48. These findings suggested that ICAM-1 in endothelial cells may act as a signaling receptor to induce Ets-1 expression in angiogenesis PMID: 11880280
  49. intestinal ischemia and reperfusion injury results in an increase of systemic ICAM-1 expression with marked organ variability PMID: 12095141
  50. study the effect of SOD on the expression of CD11b/CD18 and ICAM-1 after skeletal muscle ischemia / reperfusion injury in rats PMID: 12126535

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Subcellular Location Membrane; Single-pass type I membrane protein.
Protein Families Immunoglobulin superfamily, ICAM family
Database Links

KEGG: rno:25464

STRING: 10116.ENSRNOP00000028066

UniGene: Rn.12

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