Recombinant Human Tumor necrosis factor ligand superfamily member 10(TNFSF10),partial

In Stock
Code CSB-AP004901HU
Product Type Tumor Necrosis Factor
Size US$65
Uniprot No. P50591
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm Filtered 150 mM NaCl
Alias Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D is less than 50 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence RERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Research Area Cancer
Source E.coli
Gene Names TNFSF10
Expression Region 115-281aa
Tag Info Tag-Free
Mol. Weight 19.5 kDa
Protein Description Partial
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Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG
Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families Tumor necrosis factor family
Tissue Specificity Widespread; most predominant in spleen, lung and prostate.
Database Links

HGNC: 11925

OMIM: 603598

KEGG: hsa:8743

STRING: 9606.ENSP00000241261

UniGene: Hs.478275

Pathway Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity
FoxO signaling pathway

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