Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein(TNFSF18) (Active)

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Code CSB-AP002351HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q9UNG2
Lead Time 5-10 business days
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Storage Buffer 0.2 m filtered PBS, pH 7.4 ,lyophilized
Alias Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS
Research Area Cancer
Source E.coli
Gene Names TNFSF18
Expression Region 74-199aa
Tag Info Tag-Free
Mol. Weight 14.3 kDa
Protein Description Partial
PubMed ID 16710414; 15489334; 14702039; 12975309; 10074428; 10037686; 17449724; 23892569; 18040044
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Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1
Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families Tumor necrosis factor family
Tissue Specificity Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Database Links

HGNC: 11932

OMIM: 603898

KEGG: hsa:8995

STRING: 9606.ENSP00000385470

UniGene: Hs.248197

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