Recombinant Human Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B),partial (Active)

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Code CSB-AP004891HU
Product Type Tumor Necrosis Factor
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Uniprot No. P20333
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; TBP-2; TBPII; TNFRSF1B; TNFBR; TNFR2
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to inhibit TNFa-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TNFa is less than 0.6 ?g/mL.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source Mammalian cell
Gene Names TNFRSF1B
Expression Region 23-257aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 26.2 kDa
Protein Description Extracellular Domain
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Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted
Database Links

HGNC: 11917

OMIM: 191191

KEGG: hsa:7133

STRING: 9606.ENSP00000365435

UniGene: Hs.256278

Pathway TNF signaling pathway
Adipocytokine signaling pathway

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