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| human ENSA Expression-ready cDNA clone |
| Product Name £º |
human ENSA Expression-ready cDNA clone |
| Synonyms £º |
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| Catalog Number £º |
CSB-CL017011h |
| Relevance £º |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
| Length £º |
366 bp |
| Accession NO. £º |
NM_004436 |
| Vector £º |
PGEX-6P-1 |
| Host £º |
TOP6 |
| Form £º |
4 ug plasmid, 2ml bacterial strain, glycerol stock |
| Storage £º |
Store at -20¡æ |
| Notes £º |
Repeated freezing and thawing is not recommended. |
| Application £º |
Expression of gene directly in E. coli and not need subclone. |
| Gene sequence £º |
atgtccca gaaacaagaa gaagagaacc
ctgcggagga gaccggcgag gagaagcagg acacg
cagga gaaagaaggt attctgcctg
agagagctga agaggcaaag ctaaaggcca aataccca
ag cctaggacaa aagcctggag
gctccgactt cctcatgaag agactccaga aagggcaaaa
gtactttgac tcaggagact
acaacatggc caaagccaag atgaagaata agcagctgcc aag
tgcagga ccagacaaga
acctggtgac tggtgatcac atccccaccc cacaggatct gcccca
gaga aagtcctcgc
tcgtcaccag caagcttgcg ggtggccaag ttgaatga
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| Referrences £º |
[1] "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."
Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D.
Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed: 9653196] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
Tissue: Brain.
[2] "Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels."
Heron L., Virsolvy A., Apiou F., Le Cam A., Bataille D.
Diabetes 48:1873-1876(1999) [PubMed: 10480622] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Tissue: Brain.
[3] "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians."
Thameem F., Farook V.S., Yang X., Lee Y.-H., Permana P.A., Bogardus C., Prochazka M.
Mol. Genet. Metab. 81:16-21(2004) [PubMed: 14728987] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 5; 7 AND 8), TISSUE SPECIFICITY.
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