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human ENSA Expression-ready cDNA clone
Product Name human ENSA Expression-ready cDNA clone
Synonyms
Catalog Number CSB-CL017011h
Relevance Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Length 366 bp
Accession NO. NM_004436
Vector PGEX-6P-1
Host TOP6
Form 4 ug plasmid, 2ml bacterial strain, glycerol stock
Storage Store at -20
Notes Repeated freezing and thawing is not recommended.
Application Expression of gene directly in E. coli and not need subclone.
Gene sequence atgtccca gaaacaagaa gaagagaacc ctgcggagga gaccggcgag gagaagcagg acacg
cagga gaaagaaggt attctgcctg agagagctga agaggcaaag ctaaaggcca aataccca
ag cctaggacaa aagcctggag gctccgactt cctcatgaag agactccaga aagggcaaaa
gtactttgac tcaggagact acaacatggc caaagccaag atgaagaata agcagctgcc aag
tgcagga ccagacaaga acctggtgac tggtgatcac atccccaccc cacaggatct gcccca
gaga aagtcctcgc tcgtcaccag caagcttgcg ggtggccaag ttgaatga
Referrences [1] "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."
Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D.
Proc. Natl. Acad. Sci. U.S.A. 95:8387-8391(1998) [PubMed: 9653196] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION.
Tissue: Brain.

[2] "Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels."
Heron L., Virsolvy A., Apiou F., Le Cam A., Bataille D.
Diabetes 48:1873-1876(1999) [PubMed: 10480622] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Tissue: Brain.

[3] "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians."
Thameem F., Farook V.S., Yang X., Lee Y.-H., Permana P.A., Bogardus C., Prochazka M.
Mol. Genet. Metab. 81:16-21(2004) [PubMed: 14728987] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 5; 7 AND 8), TISSUE SPECIFICITY.

 

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