Recombinant Human C-C motif chemokine 3 protein(CCL3) (Active)

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Code CSB-AP000841HU
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P10147
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias G0/G1 switch regulatory protein 19-1, MIP-1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Research Area Immunology
Source E.coli
Gene Names CCL3
Expression Region 23-92aa
Tag Info Tag-Free
Mol. Weight 7.8 kDa
Protein Description Partial
PubMed ID 3086300; 2521882; 2271120; 1694014; 15489334; 8541527; 8525373; 7537510; 9092555; 12070155; 12401480; 10347159
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Function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Database Links

HGNC: 10627

OMIM: 182283

KEGG: hsa:6348

STRING: 9606.ENSP00000225245

UniGene: Hs.514107

Pathway Chemokine signaling pathway
Toll-like receptor signaling pathway

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