CCL19 Antibody

Datasheet
Code CSB-PA859522ZA01HU
Uniprot No. Q99731
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Human C-C motif chemokine 19 (CCL19) (22-98AA)
Raised in Rabbit
Species Reactivity Homo sapiens
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19), CCL19, ELC MIP3B SCYA19
Immunogen Species Homo sapiens (Human)
Gene Names CCL19
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
Database Links

HGNC: 10617

OMIM: 602227

KEGG: hsa:6363

STRING: 9606.ENSP00000308815

UniGene: Hs.50002

Pathway Chemokine signaling pathway
NF-kappa B signaling pathway

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