Parp Antibody

1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process. PMID: 27793508
2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin mutants. PMID: 27031963
3. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis PMID: 22242017
4. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss. PMID: 22178397
5. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility. PMID: 22184968
6. inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription PMID: 20591646
7. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements. PMID: 20371698
8. PARP-e autoregulates Parp transcription PMID: 12183365
9. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff PMID: 12543974
10. PARP1 is required for protein targeting to Cajal body. PMID: 19229318

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KEGG: dme:Dmel_CG40411

STRING: 7227.FBpp0112608

UniGene: Dm.7847