PTPRC Antibody

Datasheet
Code CSB-PA019049ZA01HU
Uniprot No. P08575
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial (24-575AA)
Raised in Rabbit
Species Reactivity Homo sapiens
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45), PTPRC, CD45
Immunogen Species Homo sapiens (Human)
Gene Names PTPRC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis (MS)
Subcellular Location Membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Database Links

HGNC: 9666

OMIM: 126200

KEGG: hsa:5788

STRING: 9606.ENSP00000356346

UniGene: Hs.654514

Pathway Fc gamma R-mediated phagocytosis
T cell receptor signaling pathway

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