PTPRC (Protein Tyrosine Phosphatase Receptor Type C), also known as CD45, is a transmembrane protein tyrosine phosphatase. It is widely expressed in immune cells such as T lymphocytes, B lymphocytes, natural killer (NK) cells, and macrophages. Its primary function is to regulate the phosphorylation levels of tyrosine residues within cells through dephosphorylation. In the activation and signal transduction processes of T and B lymphocytes, when T or B cells are stimulated by external antigens, PTPRC can remove phosphorylation modifications from specific proteins, thereby regulating the activation of signaling pathways and cell responses. The role of PTPRC in immune regulation makes it an important marker for immunotherapy. Some immunotherapeutic drugs utilize antibodies targeting PTPRC to modulate the activation and function of immune cells, thereby enhancing immune responses. PTPRC has significant clinical and scientific relevance in the field of immunotherapy and disease research.
● PTPRC Recombinant Monoclonal Antibody CSB-RA019049MA1HU
Validated Data
Overlay Peak curve showing 293 cells stained with CSB-RA019049MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following PTPRC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PTPRC Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019049KA01HU | PTPRC Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA446974 | Phospho-PTPRC (Ser1007) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-MA000202 | PTPRC Monoclonal Antibody |
Human | ELISA,WB,IHC |
CSB-PA040112 | Phospho-PTPRC (S1007) Antibody |
Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA010546 | PTPRC Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA480713 | PTPRC Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA868166 | PTPRC Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-RA019049A0HU | CD45 Recombinant Monoclonal Antibody |
Human | ELISA |
CSB-PA019049ZA01HU | PTPRC Antibody |
Homo sapiens | ELISA, WB (ensure identification of antigen) |
CSB-RA019049MA1HU | PTPRC Recombinant Monoclonal Antibody |
Human | ELISA, FC |
PTPRC Antibodies for Human
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-MA019049A0m | CD45 Monoclonal Antibody |
Human | ELISA, WB, IHC, IF, FC |
PTPRC Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial |
Yeast |
CSB-EP019049HU | Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC),Partial |
E.coli |
CSB-BP019049HU CSB-MP019049HU CSB-EP019049HU-B |
Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP019049MO CSB-EP019049MO CSB-BP019049MO CSB-MP019049MO CSB-EP019049MO-B |
Recombinant Mouse Receptor-type tyrosine-protein phosphatase C (Ptprc), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP019049RA CSB-EP019049RA CSB-BP019049RA CSB-MP019049RA CSB-EP019049RA-B |
Recombinant Rat Receptor-type tyrosine-protein phosphatase C (Ptprc), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PTPRC Proteins for Cyprinus carpio (Common carp)
Code | Product Name | Source |
---|---|---|
CSB-YP864275EQE CSB-EP864275EQE CSB-BP864275EQE CSB-MP864275EQE CSB-EP864275EQE-B |
Recombinant Cyprinus carpio Receptor-type tyrosine-protein phosphatase C (ptprc), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |