CD45 Antibody

Datasheet
Code CSB-RA019049A0HU
Size US$350
Uniprot No. P08575
Abbreviation Receptor-type tyrosine-protein phosphatase C
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen A synthesized peptide
Species Reactivity Human
Tested Applications ELISA
Relevance Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Immunology
Gene Names PTPRC
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Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)
Subcellular location Membrane, Single-pass type I membrane protein, Membrane raft
Pathway Fc gamma R-mediated phagocytosis
T cell receptor signaling pathway

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