PTPRC Antibody

Datasheet
Code CSB-PA019049KA01HU
Size US$398
Image
  • Western blot analysis of extracts of various cell lines, using PTPRC antibody.

Product Details

Uniprot No. P08575
Target Names PTPRC
Alternative Names PTPRC; B220; CD45; CD45R; GP180; LCA; LY5; T200
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of Human PTPRC
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Citations

EGFR expression in circulating tumor cells from high-grade Metastatic Sarcomas. Braun AC.et al,Cancer Biol Ther,2018

Application: Immunocytochemistry
Antibody dilution factor: 1:100
Sample type: Cells
Review: Examples of an isolated CTC of sarcoma patient with cytomorphological features negative staining for CD45, nucleus size≥12 µm, hyperchromatic and irregular nucleus, visible presence of cytoplasm, and a high nucleus–cytoplasm ratio.
PMID: 29394136

Target Data

Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis (MS)
Subcellular Location Membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Database Links

HGNC: 9666

OMIM: 126200

KEGG: hsa:5788

STRING: 9606.ENSP00000356346

UniGene: Hs.654514

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