Pkm Antibody

1. Monocrotaline-induced rats developed severe pulmonary arterial hypertension and right ventricular hypertrophy, with a significant increase in the phosphorylated PKM2 activity. PMID: 26774701
2. After light-induced retinal damage in retinal ganglion cells PKM2 was up-regulated. PMID: 25990228
3. Nuclear translocation of PKM2 promotes astrocytes proliferation after spinal cord injury through modulating p27 cell cycle signaling. PMID: 26151495
4. PKM2 may regulate the survival of cardiomyocytes in acute rejection after heart transplantation in rat PMID: 25457184
5. Data suggest M2PK is modulated in mast cell degranulation via IgE/FCERI (IgE high affinity I receptor) signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK. PMID: 24497038
6. PKM2-Oct4 interaction controls glioma cell death and differentiation. PMID: 24481450
7. Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum. PMID: 23620342
8. PanK4 interacts with Pkm2 and thereby may modulate the glucose metabolism through regulating the activity of Pkm2. PMID: 16132722
9. Age-dependent alterations in protein abundance indicated dramatic changes in metabolism, contractile activity, myofibrillar remodelling and stress response and decreased levels of pyruvate kinase. PMID: 18050275
10. Pyruvate kinase inhibition caused by cystine released from lysosomes could be one of the mechanisms of tissue damage in patients with cystinosis. PMID: 18418703
11. Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. PMID: 18587448

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KEGG: rno:25630

STRING: 10116.ENSRNOP00000015331

UniGene: Rn.1556