sod1 Antibody

Datasheet

Code	CSB-PA022397XA01DIL
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: sod1 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38 kDa Observed band size: 38 kDa
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Target Background

Product Details

Uniprot No.

O73872

Target Names

sod1

Alternative Names

Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) sod1 cuzn

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) sod1 protein (1-154aa)

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

By immunizing a rabbit with recombinant Danio rerio (Zebrafish) (Brachydanio rerio) sod1 protein (1-154aa), the sod1 polyclonal antibody is generated. This process induces an immune response in the rabbit, leading to the production of specific antibodies within the rabbit's IgG-rich serum. Following affinity chromatography purification, the resultant sod1 antibody exhibits reactivity with Danio rerio (Zebrafish) (Brachydanio rerio) sod1 protein and is extensively validated for use in ELISA and WB applications.

In Danio rerio (Zebrafish), sod1 mainly acts as an antioxidant enzyme that catalyzes the dismutation of superoxide radicals into molecular oxygen and hydrogen peroxide, thus protecting cells from the harmful effects of superoxide accumulation. This enzyme is essential for maintaining cellular redox balance and protecting cells from damage caused by reactive oxygen species.

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Target Background

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Gene References into Functions

fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1. PMID: 28290603
The earliest event in the pathophysiology of amyotrohic lateral sclerosis in the mutant sod1 zebrafish model involves neuronal stress in inhibitory interneurons, resulting from mutant Sod1 expression. PMID: 23281025
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish. PMID: 21167140
depresses cathepsin L activity stimulated by free radicals and prevents otic complications associated with bone erosion PMID: 11771045
This isoform, when expressed in PC-12 cells affects t-butylhydroperoxide-induced apoptosis differentially from its isoenzyme. PMID: 12551919
Copper/zinc superoxide dismutase was cloned from the zebrafish ( Danio rerio). Evidence is presented that SOD protects against paraquat toxicity in fish. PMID: 12876653
Glia maturation factor-null cells ahow a concurrent decrease in CuZnSOD astrocytes. PMID: 15260123

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Cu-Zn superoxide dismutase family

Database Links

KEGG: dre:30553

STRING: 7955.ENSDARP00000064375

UniGene: Dr.75822

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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sod1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background