SRC Antibody

Datasheet
Code CSB-PA022650ZA01HU
Uniprot No. P12931
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) (2-536AA)
Raised in Rabbit
Species Reactivity Homo sapiens
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src), SRC, SRC1
Immunogen Species Homo sapiens (Human)
Gene Names SRC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN)
Involvement in disease Thrombocytopenia 6 (THC6)
Subcellular Location Cell membrane, Mitochondrion inner membrane, Nucleus, Cytoplasm, cytoskeleton, Cytoplasm, perinuclear region
Protein Families Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Tissue Specificity Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Database Links

HGNC: 11283

OMIM: 190090

KEGG: hsa:6714

STRING: 9606.ENSP00000350941

UniGene: Hs.195659

Pathway Chemokine signaling pathway
ErbB signaling pathway
Estrogen signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
Adherens junction
Rap1 signaling pathway
Endocytosis
Excitatory synapse pathway

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