malE Antibody

Code CSB-PA360183ZA01ENV
Size US$299
Image
  • Western Blot
    Positive WB detected in Recombinant protein
    All lanes: malE antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 48.2 kDa
    Observed band size: 49 kDa
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Product Details

Uniprot No.
Target Names
malE
Alternative Names
Maltose-binding periplasmic protein (MBP) (MMBP) (Maltodextrin-binding protein), malE
Species Reactivity
Escherichia coli
Immunogen
Recombinant Escherichia coli Maltose-binding periplasmic protein (malE) (27-396aa)
Immunogen Species
Escherichia coli
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The malE antibody is carefully generated by immunizing a rabbit with recombinant Escherichia coli malE (27-396aa), causing the rabbit's B lymphocytes to produce specific IgG antibodies. Following this, the polyclonal malE antibody is meticulously purified from the rabbit's serum employing protein G methods. This malE antibody can be used to detect Escherichia coli malE protein in ELISA and WB tests.

The Escherichia coli MalE protein, also known as maltose-binding protein (MBP), is a member of the family of periplasmic binding proteins, involved in nutrient uptake and chemotaxis for Escherichia coli cells. malE acts as part of the maltose/maltodextrin transport system, where it captures the sugars in the periplasm and delivers them to the inner membrane transport complex. This process is crucial for the utilization of maltose as a carbon source by E. coli.

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Target Background

Function
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose.
Gene References into Functions
  1. Upon refolding, MBP initially collapses into a dynamic molten globule-like ensemble, then forms an obligatory on-pathway native-like folding intermediate that brings together sequentially remote segments and then folds globally after a long delay. PMID: 29295923
  2. Our current understanding of what makes MBP such an effective solubility enhancer for other proteins and how it facilitates the proper folding of its fusion partners is presented [REVIEW] PMID: 28132493
  3. Maltose Binding Protein is key to the coupling of maltose transport to ATP hydrolysis in vivo, because it facilitates the progression of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyze ATP PMID: 26268698
  4. activates mouse macrophages and polarizes them into M1 macrophages PMID: 24825603
  5. a salt-bridge motif in the maltose-binding protein has a role in the initial steps of substrate transport PMID: 16143635
  6. Our findings indicate that the solubility-enhancing activity of MBP is mediated by its open conformation and point to a likely role for the ligand-binding cleft in the mechanism of solubility enhancement. PMID: 17964542
  7. These data indicate that unfolding of the mature domain of preMBP is likely not a rate-determining step in translocation when the protein is targeted to the translocase via SecB. PMID: 18241889
  8. tat mutants are able to transport maltose in the absence of malE. PMID: 18385983

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Subcellular Location
Periplasm.
Protein Families
Bacterial solute-binding protein 1 family
Database Links
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