Code | CSB-E13539h |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The product CSB-E13539h is a sandwich ELISA kit developed to measure levels of human soluble receptor activator of nuclear factor-kB (sRANK) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of sRANK bound in the initial step.
RANK (CD265), encoded by the gene TNFRSF11A, is constitutively expressed in osteoclasts and dendritic cells (DCs). RANK binds to its ligand RANKL, transducing a variety of survival, proliferation, differentiation, and migration signals. These signals eventually exhibit multiple effects ranging from bone physiology, mammary gland formation, lymph node development, initiation, progression, and metastasis of breast cancer, and immune modulation. Increasing evidence has proven the value of targeting the RANKL/RANK/OPG axis not only in breast cancer but also as an addition to the cancer immunotherapy arsenal.
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