TNFRSF11A Antibody

Datasheet
Code CSB-PA925190
Former Code(s) CSB-PA086043
Size US$299
Uniprot No. Q9Y6Q6
Image
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human liver tissue, mouse kidney tissue, Primary antibody: CSB-PA925190(TNFRSF11A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthetic peptide of Human TNFRSF11A
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000
Relevance The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Immunogen Species Homo sapiens (Human)
Target Names TNFRSF11A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Involvement in disease Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein
Tissue Specificity Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Database Links

HGNC: 11908

OMIM: 174810

KEGG: hsa:8792

STRING: 9606.ENSP00000465500

UniGene: Hs.204044

Pathway NF-kappa B signaling pathway
Osteoclast differentiation

Related Products

TNFRSF11A Antibodies

TNFRSF11A Antibodies for Human

TNFRSF11A Proteins

TNFRSF11A Proteins for Homo sapiens (Human)

TNFRSF11A ELISA Kit

TNFRSF11A ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.