Mouse urokinase plasminogen activator,uPA ELISA kit

1. downregulation of uPA could decrease the fertility of male mice, which may be caused by a reduction in sperm motility. PMID: 28298247
2. data presented here reveal important information about dynamics in uPA by demonstrating how various ligands can modulate uPA activity by mediating long-range conformational changes PMID: 29420634
3. Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA; Tsc2-/- (or Tsc1-/-) embryonic fibroblasts from knockout mice express higher uPA levels than wild-type cells. (uPA = urokinase-type plasminogen activator; Tsc = tuberous sclerosis complex protein) PMID: 28972182
4. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis. PMID: 29107070
5. an intricate link between caveolin-1 and Src kinase-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C expression through p53 and uPA system-mediated cross-talk, is reported. PMID: 28385810
6. These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis. PMID: 27151212
7. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models. PMID: 26846181
8. GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model. PMID: 25753270
9. Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI. PMID: 26253597
10. we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR)-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues. PMID: 26863767
11. Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice. PMID: 25616415
12. Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA. PMID: 25979345
13. transgenic alphaMUPA mice, with genetically extended life span, showed a much slower age-related decline in the rate of wound healing than their wild-type counterparts PMID: 25960543
14. Binding of urokinase to urokinase plasminogen activator receptor promotes dendritic spine recovery and functional outcome after ischemic stroke. PMID: 25339736
15. our results suggest a role for uPA and uPAR in experimental autoimmune encephalomyelitis pathogenesis PMID: 24120085
16. Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion. PMID: 24616477
17. SERPINE2 and PLAU are involved in cumulus expansion and oocyte maturation. PMID: 24023701
18. Data suggest urokinase-type plasminogen activator (uPA) is involved in susceptibility/resistance to Group A streptococcal infection (GAS); mice expressing human plasminogen transgene are more susceptible to invasive GAS than uPA knockout mice. PMID: 23853591
19. Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations. PMID: 23236466
20. PLAU is particularly important for memory Tregs and PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways. PMID: 23169000
21. The data showed that myeloid-derived suppressor cell accumulation is tumor burden-dependent, and that tumor-derived factors such as plasminogen activator urokinase and its receptor play a role in their recruitment. PMID: 23060546
22. The study establishes the 37- and 70-loops as a unique site for binding to compounds stabilizing the active state of serine proteases. PMID: 22950516
23. Over-expression of uPA plays a synergistic role in the development of liver injury, inflammation and regeneration during acute HBV infection PMID: 22563169
24. Data presented here suggest that MMP-9 is secreted as a multiprotein complex by T. gondii infected macrophages, similar to that observed in metastatic cells. PMID: 22177333
25. u-PA and plasminogen are essential for the phagocytosis of cellular debris by macrophages during liver repair PMID: 22318286
26. Expression of ALDH1A2, BEX2, EGR2, CCL3 and PLAU are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice. PMID: 22451728
27. suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility PMID: 22280367
28. The uPA-uPAR axis has no effect on the formation of Ang II-induced abdominal aortic aneurysms, but uPA deficiency promotes aneurysmal rupture. PMID: 21868698
29. Urokinase type plasminogen activator, at concentrations found under pathological conditions, reduced pulmonary arterial contractility and increased permeability though the activation of NMDA-R1. PMID: 21617202
30. uPA acts in a cell signaling manner via binding to its receptor uPAR rather than as a protease. PMID: 21573723
31. contributes to heterogeneity of macrophages at the border of damaged site during liver repair PMID: 21301782
32. mechanisms of uPA/uPAR/plasminogen-accelerated atherosclerosis and aneurysm formation PMID: 21536666
33. The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system. PMID: 21273553
34. We propose that u-PA has a protective role in arthritis models with 'wound healing-like' processes following local trauma PMID: 20973954
35. Early experimental venous thrombus resolution is independent of uPA. PMID: 20886179
36. study investigated whether host uPA is a crucial protagonist for the TIMP-1-induced modulation of a pro-metastatic microenvironment in the liver PMID: 19863693
37. uPA/uPAR downregulation suppresses angiogenesis in endothelial cells induced by glioblastoma cell lines PMID: 20805979
38. Selective abrogation of the uPA-uPAR interaction is associated with suppression of fibrin-associated inflammation. PMID: 20466854
39. u-PA is required for the full development of systemic arthritis models involving immune complex formation and deposition. PMID: 20196869
40. uPA plays a critical role in BV-2 microglial cell migration by activating pro-MMP-9, in part by its direct action on MMP-9 and also in part by the activation of plasminogen/plasmin cascade. PMID: 20177776
41. uPA deficiency can unfavorably modulate both delayed neurodegeneration and neurogenesis but has little effect on post-injury neuronal migration and vascular density. Elevated uPA during the post-injury phase is neuroprotective. PMID: 20026272
42. MAPK pathways ERK, JNK/SAPK, and P38-MAPK represent a significant component in the regulation of u-PA expression in human prostate cancer. PMID: 11676474
43. During infection with Cryptococcus neoformans, mice genetically deficient in uPA have a decreased number of recruited effector T cells in the lung, fail to generate a protective T1 profile of cytokines, and display impaired antifungal activity. PMID: 11777975
44. u-PA-/- mice developed significantly milder disease compared with the relevant wild-type mice PMID: 11891190
45. fibrinolysis by uPA-dependent plasmin activity plays a fundamental role in skeletal muscle regeneration PMID: 11929773
46. that u-PA plays important roles in liver regeneration after hepatectomy through control of a transcription factor, c-jun expression. PMID: 11983447
47. the role of urokinase in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions PMID: 12183060
48. uPA regulated by heregulin in mouse neoplasms PMID: 12209601
49. inducible expression reduces fibrosis and mortality after lung injury in mice PMID: 12376355
50. These results suggest that increasing uPA expression by an appropriate combination of growth factors and ECM components constitutes a possible approach to improving the migration of myogenic cells after transplantation. PMID: 12413883

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KEGG: mmu:18792

STRING: 10090.ENSMUSP00000022368

UniGene: Mm.4183