Recombinant Human Placenta growth factor protein(PGF) (Active)

Code CSB-AP002731HU
Product Type Growth Factor
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P49763
Storage Buffer 0.2 μm filtered PBS, pH 7.4, with 0.02 % Tween-20 ,lyophilized
Alias PlGF
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biologically active as determined by its ability to chemoattract human monocytes using a concentration range of 5.0-50 ng/ml.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR
Research Area Cancer
Source E.coli
Gene Names PGF
Expression Region 19-170aa
Product Info Tag-Free
Mol. Weight 34.6 kDa
Protein Description Full Length of Isoform PlGF-2
PubMed ID 1924389; 8148155; 7681160; 9207183; 12508121; 15489334; 7929268; 21215706; 11069911
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Function Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Subcellular Location Secreted
Protein Families PDGF/VEGF growth factor family
Tissue Specificity While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Database Links

HGNC: 8893

OMIM: 601121

KEGG: hsa:5228

STRING: 9606.ENSP00000451040

UniGene: Hs.252820

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Ras signaling pathway
Rap1 signaling pathway

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