Recombinant Human Interleukin-2(IL2),partial (Active) (GMP)

In StockGMP
Code CSB-AP005811HU
Product Type Interleukin
Size $1047Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P60568
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 3.5.
Alias T-cell growth factor,TCGF,INN: Aldesleukin,IL-2
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 IU/mg.
Purity > 98 % by SDS-PAGE and HPLC analyses.
Endotoxin Less than 0.01 EU/μg of rHuIL-2 GMP as determined by LAL method.
Sequence APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Research Area Immunology
Source E.Coli
Gene Names IL2
Expression Region 21-153aa
Tag Info Tag-Free
Mol. Weight 15.4 kDa
Protein Description Partial
PubMed ID 6312994; 6403867; 6306584; 6324170; 6330695; 6608729; 7722480; 8824916; 15489334; 3491296; 3264184; 6333684; 2793860; 1396583; 3500515; 1631562; 1510960; 7529123; 16293754; 16477002
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Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Subcellular Location Secreted
Protein Families IL-2 family
Database Links

HGNC: 6001

OMIM: 147680

KEGG: hsa:3558

STRING: 9606.ENSP00000226730

UniGene: Hs.89679

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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