Recombinant Mouse Interleukin-2 protein(Il2) (Active)

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Code CSB-AP003281MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P04351
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IL-2, TCGF
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0x106 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ
Research Area Immunology
Source E.coli
Gene Names Il2
Expression Region 21-169aa
Tag Info Tag-Free
Mol. Weight 17.2 kDa
Protein Description Full Length of Mature Protein
PubMed ID 6240025; 2578624; 3918306; 3003564; 10779485; 19468303; 1420317; 8319981; 8262055
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Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Subcellular Location Secreted
Protein Families IL-2 family
Database Links

KEGG: mmu:16183

STRING: 10090.ENSMUSP00000029275

UniGene: Mm.14190

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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